Magnetic resonance imaging of amyloid plaque in the brain
US-9320452-B2 · Apr 26, 2016 · US
US9995803B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9995803-B2 |
| Application number | US-201414508920-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 7, 2014 |
| Priority date | Mar 8, 2010 |
| Publication date | Jun 12, 2018 |
| Grant date | Jun 12, 2018 |
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A progressive series of five new coils is described. The first coil solves problems of transmit-field inefficiency and inhomogeneity for heart and body imaging, with a close-fitting, 16-channel TEM conformal array design with efficient shield-capacitance decoupling. The second coil progresses directly from the first with automatic tuning and matching, an innovation of huge importance for multi-channel transmit coils. The third coil combines the second, auto-tuned multi-channel transmitter with a 32-channel receiver for best transmit-efficiency, control, receive-sensitivity and parallel-imaging performance. The final two coils extend the innovative technology of the first three coils to multi-nuclear ( 31 P— 1 H) designs to make practical human-cardiac imaging and spectroscopy possible for the first time at 7 T.
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What is claimed is: 1. An apparatus comprising: a coil for operation in a magnetic-resonance machine that operates at a given magnetic field strength, the coil including: a plurality of coil elements, a plurality of inner shield elements, a plurality of transmit-receive circuits, wherein each one of the plurality of transmit-receive circuits includes a respective transmit amplifier operatively coupled through a first respective non-magnetic variable capacitance to its respective one of the plurality of coil elements, and wherein each one respective of the plurality of inner shield elements is operatively coupled through a second respective non-magnetic variable capacitance to its respective one of the plurality of coil elements; and a computer operatively coupled to control a capacitance value of each one of the first respective non-magnetic variable capacitances, and to control a capacitance value of each one of the second respective non-magnetic variable capacitances to automatically tune resonance frequency and match impedance of each of the plurality of coil elements. 2. The apparatus of claim 1 , further comprising a plurality of outer shield elements, wherein each one of the plurality of outer shield elements overlaps two of the plurality of inner shield elements. 3. The apparatus of claim 1 , wherein the plurality of coil elements that the computer automatically tunes the resonance frequency of and matches the impedance of includes both transmit elements and receive elements. 4. The apparatus of claim 1 , wherein the plurality of circuit elements includes mechanically tunable inductance. 5. The apparatus of claim 1 , wherein each first respective non-magnetic variable capacitance of the plurality of transmit-receive circuits includes a mechanically tunable capacitor in series with its respective transmit one of the plurality of coil elements, and wherein the computer causes a mechanical tuning of each first respective variable capacitance of the plurality of transmit-receive circuits. 6. The apparatus of claim 1 , wherein the plurality of coil elements includes a plurality of transmit elements, and wherein each of the plurality of transmit-receive circuits includes a mechanically tunable inductance in each of the plurality of transmit elements. 7. The apparatus of claim 1 , wherein the plurality of coil elements includes a plurality of coaxial TEM coil elements, wherein each coaxial TEM coil element includes an inner conductor and an outer conductor that are movable lengthwise relative to one another, and wherein the computer causes a mechanical lengthwise position adjustment of each respective inner conductor and outer conductor position relative to one another for each respective one of the plurality of coaxial TEM coil elements. 8. The apparatus of claim 1 , wherein the given magnetic-field strength at which the coil operates is at least seven tesla. 9. A computer implemented method comprising: providing a coil for operation in a magnetic-resonance machine that operates at a given magnetic field strength, the coil including a plurality of N coil elements, a plurality of N inner shield elements, and a plurality of N transmit-receive circuits, wherein each one of the plurality of N transmit-receive circuits includes a respective transmit amplifier operatively coupled through a first respective non-magnetic variable capacitance to its respective one of the plurality of N coil elements, wherein each respective one of the plurality of N inner shield elements is operatively coupled through a second respective non-magnetic variable capacitance to its respective one of the plurality of N coil elements, and wherein N is an integer greater than one; setting, by a computer, electrical parameters of each of the plurality of coil elements to approximate values of resonance frequency and matched impedance; automatically adjusting, by the computer, each respective first non-magnetic variable capacitance to adjust a frequency-tuning match and automatically adjusting each respective second non-magnetic variable capacitance to adjust an impedance match of the Nth coil element; repeating the automatically adjusting, by the computer, of the first and second respective non-magnetic variable capacitance for each of the plurality of coil elements in turn until an amount of change at every coil element is below a predetermined criterion change amount; and obtaining a magnetic-resonance image using the magnetic-resonance coil. 10. The method of claim 9 , further comprising: providing a plurality of outer shield elements; and positioning each one of the plurality of outer shield elements to overlap two of the plurality of inner shield elements. 11. The method of claim 9 , wherein the plurality of coil elements includes both transmit elements and receive elements, and wherein the automatically adjusting each respective first non-magnetic variable capacitance is performed for both transmit and receive elements. 12. The method of claim 9 , wherein each one of the plurality of circuit elements includes a mechanically tunable inductance. 13. The method of claim 9 , wherein each first respective non-magnetic variable capacitance of the plurality of transmit-receive circuits includes a mechanically tunable capacitor in series with its respective transmit one of the plurality of coil elements, and wherein the automatically adjusting of each respective first non-magnetic variable capacitance includes mechanically tuning each first respective variable capacitance of the plurality of transmit-receive circuits. 14. The method of claim 9 , wherein the plurality of coil elements includes a plurality of transmit elements, and wherein the method further includes mechanically tuning an inductance in each of the plurality of transmit elements. 15. The method of claim 9 , wherein the plurality of coil elements includes a plurality of coaxial TEM coil elements, wherein each coaxial TEM coil element includes an inner conductor and an outer conductor that are movable lengthwise relative to one another, and wherein the method further includes mechanical adjusting lengthwise positions of each respective inner conductor and outer conductor position relative to one another for each respective one of the plurality of coaxial TEM coil elements. 16. An apparatus comprising: a coil for operation in a magnetic-resonance machine that operates at a given magnetic field strength, the coil including: a plurality of N coil elements, a plurality of N inner shield elements, and a plurality of N transmit-receive circuits, wherein each one of the plurality of N transmit-receive circuits includes a respective transmit amplifier operatively coupled through a first respective non-magnetic variable capacitance to its respective one of the plurality of N coil elements, wherein each respective one of the plurality of N inner shield elements is operatively coupled through a second respective non-magnetic variable capacitance to its respective one of the plurality of N coil elements, and wherein N is an integer greater than one; means for setting each of the plurality of coil elements to approximate values of resonance frequency and matched impedance; means for automatically adjusting each respective first non-magnetic variable capacitance to adjust a frequency-tuning match, means for automatically adjusting each respective second non-magnetic variable capacitance to adjust an impedance match; means for repeating the automatically adjusting of the first and second respective non-magnetic variable capacitance for each of the plurality of coil eleme
caused by a distortion of the RF magnetic field, e.g. spatial inhomogeneities of the RF magnetic field (G01R33/56509, G01R33/56518, G01R33/56536 take precedence) · CPC title
Transverse electromagnetic [TEM] coils · CPC title
Signal processing systems, e.g. using pulse sequences {; Generation or control of pulse sequences; Operator console} · CPC title
comprising arrays of sub-coils {, i.e. phased-array coils with flexible receiver channels} · CPC title
Decoupling of multiple RF coils wherein the multiple RF coils have the same function in MR, e.g. decoupling of a receive coil from another receive coil in a receive coil array, decoupling of a transmission coil from another transmission coil in a transmission coil array · CPC title
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