Biodegradable protrusions on inflatable device

Patent metadata

Field	Value
Publication number	US-9993625-B2
Application number	US-201113203765-A
Country	US
Kind code	B2
Filing date	Jan 28, 2011
Priority date	Jan 29, 2010
Publication date	Jun 12, 2018
Grant date	Jun 12, 2018

Abstract

A medical device for insertion and expansion in a body passageway. The medical device includes an inflatable device such as a balloon that is designed to be inflated and deflated while positioned in the body passageway. The inflatable device is inflatable by inserting a fluid in an internal cavity of the inflatable device. The inflatable device includes an outer surface that has a surface structure or micro-surface structure which is designed to at least partially penetrate into an inner wall of the body passageway when the inflatable device is inflated.

First claim

What is claimed is:

1. A medical device for insertion and inflation in a body passageway, said medical device including an inflatable device that is designed to be inflated and deflated while positioned in the body passageway, said inflatable device is inflatable by inserting a fluid in an internal cavity of an inflatable body of said inflatable device, said inflatable body having an outer surface, said outer surface includes a surface structure or micro-surface structure that is configured to at least partially penetrate into an inner wall of the body passageway when said inflatable device is inflated, said surface structure or micro-surface structure includes a top portion, said top portion formed of a biodegradeble or bioabsorbable material, said top portion including a biological agent, said top portion including an upper region and a narrow region, said narrow region having a cross-section size that is less than a cross-section size of said upper region where said narrow region connects to said upper region, said top portion is configured to detach from a lower body of said surface structure or micro-surface structure at a narrow region of said top portion, said lower body including a base that engages said inflatable body and an upper region having a cavity, said cavity configured to telescopically receive at least a portion of said narrow region of said top portion.

2. The medical device as defined in claim 1 , wherein said lower body of said surface structure or micro-surface structure includes an internal passageway, said internal passageway fluidly connected to said internal cavity of said inflatable body to enable fluid to flow from said internal cavity and through said internal passageway of said body portion of said surface structure, said fluid flow through said internal passageway at least partially causing said top portion of said surface structure or micro-surface structure to release from said lower body of said surface structure or micro-surface structure.

3. The medical device as defined in claim 1 , wherein said top portion is configured to resist detachment from the body passageway once said top portion has penetrated into the wall of the body passageway, said top portion a) having a top-shaped portion, b) having an arrow-head shaped portion, c) including a barb, d) including non-smooth surfaces, e) including angled fibers, f) including a spike, or some combination of a)-f) that facilitate in resisting detachment of said top portion from the body passageway.

4. The medical device as defined in claim 1 , wherein said outer surface of said inflatable body of said inflatable device includes a plurality of said surface structures or micro-surface structures, said plurality of said surface structures or micro-surface structures a) positioned and spaced uniformly on said outer surface of said inflatable body of said inflatable device, b) positioned and spaced non-uniformly on said outer surface of said inflatable body of said inflatable device, c) positioned only on certain regions on said outer surface of said inflatable body of said inflatable device, d) positioned in bands on said outer surface of said inflatable body of said inflatable device, or some combination of a)-d).

5. A method of delivering a biological agent to a body passageway including:
providing inflatable device having an inflatable body, said inflatable body including at least one surface structure or micro-surface structure located on an outer surface of said inflatable body, said at least one surface structure or micro-surface structure configured to at least partially penetrate into an inner wall of the body passageway when said inflatable device is inflated, said surface structure or micro-surface structure includes a top portion, said top portion formed of a biodegradable or bioabsorbable material, said top portion including biological agent, said top portion including an upper region and a narrow region, said narrow region having a cross-section size that is less than a cross-section size of said upper region where said narrow region connects to said upper region, said top portion is configured to detach from a lower body of said surface structure or micro-surface structure at a narrow region of said top portion, said lower body including a base that engages said inflatable body and an upper region having a cavity, said cavity configured to telescopically receive at least a portion of said narrow region of said top portion;
positioning said inflatable device in the body passageway while said inflatable device is not fully inflated;
inserting fluid into an inner cavity of said inflatable body of said inflatable device to cause said inflatable body to inflate and to expand such that at least a part of said top portion of at least one of said surface structures or micro-surface structures penetrates an inner surface wall of said body passageway;
locally delivering biological agent to said inner surface wall of said body passageway by said at least one surface structure or micro-surface structure via said penetration of said top portion of said surface structure or micro-surface structure into said body passageway;
at least partially deflating said inflatable body to cause said top portion of said at least one surface structure or micro-surface structure that has penetrated into said body passageway to slidably separate from said upper region of said lower body of said at least one surface structure or micro-surface structure; and,
removing said inflatable device from said body passageway while at least a portion of said at least one surface structure or micro-surface structure remains in said body passageway.

6. The method as defined in claim 5 , wherein said body portion of said surface structure or micro-surface structure includes an internal passageway, said internal passageway fluidly connected to said internal cavity of said inflatable body to enable fluid to flow from said internal cavity and through said cavity of said lower body of said surface structure, said fluid flow through said cavity of said lower body at least partially causing said top portion of said surface structure or micro-surface structure to release from said lower body of said surface structure or micro-surface structure.

7. The method as defined in claim 6 , wherein said top portion is configured to detach from or break-off from a body portion of said surface structure or micro-surface structure after being a) subjected to a certain amount of fluid pressure from fluid in said internal cavity, b) subjected to electrical current, c) subjected to electromagnetic radiation, d) subjected to a chemical reaction, e) subjected to ultrasonic waves, or some combination of a)-e).

Assignees

• Roth Noah
• Patel Udayan
• Mirus Llc

Inventors

• Roth Noah
• Patel Udayan

Classifications

• A61M37/0015

  by using microneedles · CPC title

• A61F2220/0016

  with sharp anchoring protrusions, e.g. barbs, pins, spikes · CPC title

• A61M25/10 Primary

  Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00}) · CPC title

• A61M2025/1004

  Balloons with folds, e.g. folded or multifolded · CPC title

• A61F2/958

  Inflatable balloons for placing stents or stent-grafts · CPC title