Method of improving visual processing, visual acuity, or both by administering compositions comprising RRR-alpha-tocopherol and carotenoid to infants

Patent metadata

Field	Value
Publication number	US-9993457-B2
Application number	US-201515529305-A
Country	US
Kind code	B2
Filing date	Nov 25, 2015
Priority date	Nov 25, 2014
Publication date	Jun 12, 2018
Grant date	Jun 12, 2018

Abstract

Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are also disclosed. Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.

First claim

What is claimed is:

1. A method of improving the visual processing of a healthy infant, the method comprising administering a nutritional composition comprising RRR-alpha-tocopherol and a carotenoid to the infant.

2. The method of claim 1 wherein the carotenoid is selected from the group consisting of α-carotene, β-carotene, γ-carotene, lycopene, lutein, zeaxanthin, astaxanthin, α-cryptoxanthin, β-cryptoxanthin, and combinations thereof.

3. The method of claim 1 wherein the nutritional composition delivers about 0.5 mg to about 100 mg RRR-alpha-tocopherol per day to the infant, and wherein the carotenoid is selected from the group consisting of:
a) β-carotene, and the nutritional composition delivers about 5 μg to about 160 mg β-carotene per day to the infant;
b) lycopene, and the nutritional composition delivers about 1.4 μg to about 180 mg lycopene per day to the infant;
c) lutein, and the nutritional composition delivers about 1 μg to about 240 mg lutein per day to the infant;
d) zeaxanthin, and the nutritional composition delivers about 1 μg to about 180 mg zeaxanthin per day to the infant;
e) α-carotene, and the nutritional composition delivers about 1 μg to about 180 mg α-carotene per day to the infant;
f) α-cryptoxanthin, and the nutritional composition delivers about 0.5 μg to about 90 mg α-cryptoxanthin per day to the infant; and
g) combinations thereof.

4. The method of claim 1 wherein the nutritional composition is an infant nutritional formula comprising about 2% to about 75% protein, about 1% to about 85% carbohydrate, and about 5% to about 70% fat as percentages of the total calories.

5. The method of claim 1 wherein the nutritional composition is a vitamin composition.

6. The method of claim 5 wherein the vitamin composition is in a form selected from the group consisting of tablets, chewable tablets, capsules, powders, aqueous liquids, oil-based liquids, slurries, syrups, elixirs, and combinations thereof.

7. The method of claim 5 wherein the vitamin composition further comprises at least one of Vitamin A, Vitamin D, Vitamin K, Coenzyme Q 10 , α-linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and combinations thereof.

8. The method of claim 1 wherein the infant is a premature infant or wherein the infant does not have ocular disease.

9. A method of improving the visual acuity of a healthy infant, the method comprising administering a nutritional composition comprising RRR-alpha-tocopherol and a carotenoid to the infant.

10. The method of claim 9 wherein the nutritional composition delivers about 0.5 mg to about 100 mg RRR-alpha-tocopherol per day to the infant, and wherein the carotenoid is selected from the group consisting of:
a) β-carotene, and the nutritional composition delivers about 5 μg to about 160 mg β-carotene per day to the infant;
b) lycopene, and the nutritional composition delivers about 1.4 μg to about 180 mg lycopene per day to the infant;
c) lutein, and the nutritional composition delivers about 1 μg to about 240 mg lutein per day to the infant;
d) zeaxanthin, and the nutritional composition delivers about 1 μg to about 180 mg zeaxanthin per day to the infant;
e) α-carotene, and the nutritional composition delivers about 1 μg to about 180 mg α-carotene per day to the infant;
f) α-cryptoxanthin, and the nutritional composition delivers about 0.5 μg to about 90 mg α-cryptoxanthin per day to the infant; and
g) combinations thereof.

11. The method of claim 9 wherein the nutritional composition is an infant nutritional formula comprising about 2% to about 75% protein, about 1% to about 85% carbohydrate, and about 5% to about 70% fat as percentages of the total calories.

12. The method of claim 9 wherein the nutritional composition is a vitamin supplement.

13. The method of claim 12 wherein the vitamin supplement is in a form selected from the group consisting of tablets, chewable tablets, capsules, powders, aqueous liquids, oil-based liquids, slurries, syrups, elixirs, and combinations thereof.

14. The method of claim 12 wherein the vitamin supplement further comprises at least one of Vitamin A, Vitamin D, Vitamin K, Coenzyme Q 10 , α-linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and combinations thereof.

15. The method of claim 9 wherein the nutritional composition is administered at least once per day.

16. The method of claim 9 wherein the infant is a premature infant.

17. The method of any claim 9 wherein the infant does not have ocular disease.

18. The method of claim 9 wherein the carotenoid is selected from the group consisting of α-carotene, β-carotene, γ-carotene, lycopene, lutein, zeaxanthin, astaxanthin, α-cryptoxanthin, β-cryptoxanthin, and combinations thereof.

19. A method of improving the development of both visual processing and visual acuity in an infant, the method comprising administering a nutritional composition comprising RRR-alpha-tocopherol and a carotenoid to the infant, wherein the carotenoid is selected from the group consisting of α-carotene, β-carotene, γ-carotene, lycopene, lutein, zeaxanthin, astaxanthin, α-cryptoxanthin, β-cryptoxanthin, and combinations thereof.

Assignees

• Abbott Lab

Inventors

• Kuchan Matthew
• Lai Chron-Si
• Boff Jacqueline

Classifications

• A23L33/155

  Vitamins A or D · CPC title

• A23L33/40

  Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title

• A23L33/12

  Fatty acids or derivatives thereof · CPC title

• A61K31/015

  carbocyclic · CPC title

• A23L33/15

  Vitamins · CPC title