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Diagnosing and treating alzheimer's disease
US9989541B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9989541-B2 |
| Application number | US-201415103059-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 23, 2014 |
| Priority date | Dec 27, 2013 |
| Publication date | Jun 5, 2018 |
| Grant date | Jun 5, 2018 |
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Abstract
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Described herein are methods, systems and compositions for the diagnosis, prognosis and treatment of dementia and Alzheimers disease. Also described are methods, systems and compositions to distinguish between Alzheimers disease and Parkinsons disease. In various embodiments levels of PACAP and/or SIRT3 are analyzed for the diagnosis, prognosis and treatment of dementia and Alzheimers disease.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of treating late onset Alzheimer' s disease in an individual, comprising: providing a composition comprising PACAP, analogs thereof, salts thereof, or combinations thereof, and a pharmaceutically acceptable carrier; and administering a therapeutically effective dosage of the composition to the individual who has been determined to have late onset Alzheimer's disease based on a level of PACAP protein present in the individual's cerebrospinal fluid. 2. The method of claim 1 , the individual has been determined to have a PACAP protein level in the individual's cerebrospinal fluid below a reference value. 3. A method for treating late onset Alzheimer's disease in a subject, comprising: obtaining the results of an analysis of a PACAP protein level in a subject's cerebrospinal fluid; and administering a composition comprising PACAP to the subject when the PACAP protein level in the subject's cerebrospinal fluid is below a reference value. 4. The method of claim 3 , wherein the method comprises obtaining the results of an analysis for both a PACAP level and a SIRT3 level in the subject's cerebrospinal fluid.
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Classifications
- G01N33/6896Primary
Neurological disorders, e.g. Alzheimer's disease · CPC title
Dementia; Cognitive disorders · CPC title
Alzheimer · CPC title
Hydrolases (3) · CPC title
Assays involving proteins of known structure or function as defined in the subgroups · CPC title
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Frequently asked questions
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- What does patent US9989541B2 cover?
- Described herein are methods, systems and compositions for the diagnosis, prognosis and treatment of dementia and Alzheimers disease. Also described are methods, systems and compositions to distinguish between Alzheimers disease and Parkinsons disease. In various embodiments levels of PACAP and/or SIRT3 are analyzed for the diagnosis, prognosis and treatment of dementia and Alzheimers disease.
- Who is the assignee on this patent?
- Dignity Health
- What technology area does this patent fall under?
- Primary CPC classification G01N33/6896. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jun 05 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).