Novel Histamine Releaser Contained in Human Sweat
US-2015238581-A1 · Aug 27, 2015 · US
Monoclonal IgE antibody that binds to sweat allergy antigen protein
US9989538B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9989538-B2 |
| Application number | US-201314421821-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 9, 2013 |
| Priority date | Aug 17, 2012 |
| Publication date | Jun 5, 2018 |
| Grant date | Jun 5, 2018 |
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- Title
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Abstract
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Provided include a human IgE antibody that binds to a sweat allergy antigen protein and a human high-affinity IgE receptor but does not induce degranulation in a reaction with the sweat allergy antigen protein, and a composition for treatment or diagnosis of sweat allergy comprising the same.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of measuring an amount of a sweat allergy antibody in a sample from a human, comprising (a) contacting the sample comprising the sweat allergy antibody with a sweat allergy antigen protein having an amino acid sequence consisting of SEQ ID NO: 1 to form a complex and detecting the complex; and (b) determining the amount of the sweat allergy antibody in the sample based on a standard curve prepared by contacting a known concentration of a standard antibody with the sweat allergy antigen protein having an amino acid sequence consisting of SEQ ID NO: 1, wherein the standard antibody is a human IgE monoclonal antibody, clone HE1, that specifically binds to the sweat allergy antigen protein having an amino acid sequence consisting of SEQ ID NO: 1. 2. The method of claim 1 , wherein the sweat allergy antibody is an IgE antibody. 3. The method of claim 1 , wherein the amount of the sweat allergy antibody is measured in an ELISA plate on which the sweat allergy antigen protein is immobilized or an ELISA plate on which the sample is immobilized. 4. The method of claim 1 , wherein said standard antibody does not induce degranulation in a reaction with the sweat allergy antigen protein having an amino acid sequence consisting of SEQ ID NO: 1.
Assignees
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Classifications
Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title
- C07K16/14Primary
against material from fungi, algea or lichens · CPC title
against material from animals or humans · CPC title
against enzymes · CPC title
from primates, e.g. man · CPC title
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Frequently asked questions
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- What does patent US9989538B2 cover?
- Provided include a human IgE antibody that binds to a sweat allergy antigen protein and a human high-affinity IgE receptor but does not induce degranulation in a reaction with the sweat allergy antigen protein, and a composition for treatment or diagnosis of sweat allergy comprising the same.
- Who is the assignee on this patent?
- Univ Hiroshima
- What technology area does this patent fall under?
- Primary CPC classification C07K16/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 05 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).