Assembly for a drug delivery device and method of operating the same

Patent metadata

Field	Value
Publication number	US-9987433-B2
Application number	US-201414905446-A
Country	US
Kind code	B2
Filing date	Jul 17, 2014
Priority date	Jul 17, 2013
Publication date	Jun 5, 2018
Grant date	Jun 5, 2018

Abstract

An assembly for a drug delivery device ( 200 ) is presented which comprises a housing ( 24 ) having a proximal end ( 25 ) and a distal end ( 26 ), a cartridge, a plunger ( 19 ) which is movably retained in the cartridge ( 14 ) and a piston rod ( 6 ). The assembly further comprises a rod displacement feature ( 33 ). The assembly is configured such that, in an initial state of the assembly, the piston rod ( 6 ) and the rod displacement feature ( 33 ) are arranged such that movement of the rod displacement feature ( 33 ) from the first position to the second position is transferred to the piston rod ( 6 ) such that the piston rod ( 6 ) is moved with respect to the cartridge ( 14 ) and the assembly is switched from the initial state to a primed state. In the primed state, movement of the rod displacement feature ( 33 ) from the first position to the second position is not transferred to the piston rod ( 6 ).

First claim

The invention claimed is:

1. An assembly for a drug delivery device, the assembly comprising:
a housing having a proximal end and a distal end,
a cartridge, a plunger being movably retained in the cartridge,
a piston rod arranged to move the plunger distally with respect to the cartridge, and
a rod displacement feature movable between first and second positions with respect to the housing, wherein the assembly is configured such that, in an initial state of the assembly, the piston rod and the rod displacement feature are arranged such that movement of the rod displacement feature from the first position to the second position is transferred to the piston rod such that the piston rod is moved with respect to the cartridge and the assembly is switched from the initial state to a primed state and wherein, in the primed state, movement of the rod displacement feature from the first position to the second position is not transferred to the piston rod.

2. The assembly according to claim 1 , wherein, when the assembly is switched from the initial state to the primed state, the plunger is moved with respect to the cartridge and an initial static friction force between the plunger and the cartridge is overcome.

3. The assembly according to claim 2 , wherein the plunger and the cartridge are configured such that the initial static friction force is between 10 N and 20 N.

4. The assembly according to claim 2 , comprising a drive mechanism being configured to transfer a driving force to the piston rod in the primed state.

5. The assembly according to claim 4 , wherein the drive mechanism is configured such that the driving force is between 3 N and 10 N.

6. The assembly according to claim 4 , wherein the initial static friction force is greater than the driving force.

7. The assembly according to claim 4 , wherein the rod displacement feature comprises a displacement member of the drive mechanism, wherein the displacement member is movable to selectively couple a drive member to the piston rod in order to transfer the driving force to the piston rod.

8. The assembly according to claim 7 , comprising a drive spring being arranged and configured to drive the movement of the piston rod via the drive member by a driving force generated by a drive spring, whereby the driving force is exerted on the piston rod.

9. The assembly according to claim 1 , comprising a spring element which is arranged and configured such that movement of the rod displacement feature from the first position to the second position loads the spring element and the spring force of the spring element moves the rod displacement feature back into the first position.

10. The assembly according to claim 1 , comprising a dose button, the dose button being arranged and configured such that movement of the dose button with respect to the housing initiates a delivery of a dose of a drug, wherein the movement of the dose button is at least partly transferred to the rod displacement feature.

11. The assembly according to claim 1 , comprising a coupling element, wherein a uni-directional coupling is formed between the piston rod and the coupling element and wherein the coupling element is fixed to the housing and arranged and configured such that a proximal movement of the piston rod with respect to the housing is prevented.

12. The assembly according to claim 1 , wherein, in the initial state, an initial content of a drug is retained in the cartridge.

13. The assembly according to claim 1 , wherein in the initial state, the distance between a proximal face of the piston rod and a distal face of the rod displacement feature is smaller than the distance between the first position and the second position.

14. The assembly according to claim 1 , wherein, in the initial state, a distance between the plunger and the piston rod is smaller than a distance between the first position and the second position of the rod displacement feature.

15. The assembly according to claim 1 , wherein the direction of movement of the rod displacement feature from the first position to the second position is the distal direction.

16. A method of operating a drug delivery device comprising the steps of:
moving a rod displacement feature of the drug delivery device from a first position to the second position with respect to a housing of the drug delivery device, wherein said movement is transferred to a piston rod such that the piston rod is moved with respect to a cartridge disposed in the housing and the assembly is switched from the initial state to a primed state; and
moving the rod displacement feature from the first position to a second position with respect to the housing, wherein said movement is not transferred to the piston rod.

Assignees

• Sanofi Sa

Inventors

• Oakley Tom
• Schumann Matt
• Milne Stuart

Classifications

• A61M5/3157

  Means providing feedback signals when administration is completed (A61M5/20 takes precedence) · CPC title

• A61M5/20

  Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 {, A61M5/46} take precedence; {hypodermic projectiles F42B12/54}) · CPC title

• A61M5/31553

  without axial movement of dose setting member · CPC title

• A61M5/31561

  using freely adjustable volume steps · CPC title

• A61M5/31573

  Accuracy improving means · CPC title