Methods and systems for priming a biological fluid processing circuit

Patent metadata

Field	Value
Publication number	US-9987411-B2
Application number	US-201414577283-A
Country	US
Kind code	B2
Filing date	Dec 19, 2014
Priority date	Dec 19, 2014
Publication date	Jun 5, 2018
Grant date	Jun 5, 2018

Abstract

Methods and systems for priming biological fluid processing systems are disclosed. In accordance with such methods and systems, the disposable fluid processing circuit is primed by introducing a first priming solution into a portion of the circuit and a second priming solution into a portion of the circuit. The amount of citrate returned to the biological flood source is minimized.

First claim

The invention claimed is:

1. A method of priming a blood processing circuit prior to a blood processing protocol comprising:
a) mounting a biological fluid processing circuit that includes a biological fluid processor, a reservoir, one or more containers of processing solutions, a biological fluid access device and a flow path establishing flow communication between said one or more solutions, a source of biological fluid, onto a hardware component of a biological fluid processing system in a predetermined relationship;
b) selecting a biological fluid processing protocol;
c) introducing a first solution from a first container of a processing solution and flowing said first solution through a portion of said processing circuit;
d) monitoring for the presence of liquid at a detection point of said circuit;
e) detecting the presence of liquid in said circuit at said detection point;
f) upon said detecting, introducing a further amount of said first solution into said fluid circuit, wherein said amount is sufficient to deliver said first solution to a selected point of said flow path;
g) introducing a fluid from a source other than said first container into said flow path and through at least a portion of said processing circuit that is different from the portion through which said first solution is flowed.

2. The method of claim 1 wherein said fluid comprises a second solution from a second container.

3. The method of claim 2 wherein said step of introducing said second solution is determined by the blood processing protocol selected.

4. The method of claim 3 wherein said selected blood processing protocol comprises returning one or more blood components to a blood source and delivering a replacement fluid to said source.

5. The method of claim 2 wherein said first solution comprises anticoagulant and said second solution comprises a replacement fluid.

6. The method of claim 5 wherein said replacement fluid comprises saline.

7. The method of claim 1 wherein said volume of said first solution is between 10 ml and 30 ml.

8. The method of claim 7 wherein said first solution includes citrate.

9. The method of claim 1 comprising monitoring the volume of said introduced first solution.

10. The method of claim 9 comprising monitoring said volume by observing changes in the weight of said first container.

11. The method of claim 9 comprising monitoring said volume by determining the number of pump strokes in a pump associated with said introduced first solution.

12. The system of claim 1 wherein said fluid is blood.

13. The system of claim 12 wherein said controller is configured to deliver said blood to said different portion of said processing circuit.

14. The method of claim 1 further comprising selecting a biological fluid processing protocol from a first protocol wherein a replacement fluid is administered to a subject and a second protocol wherein no replacement fluid is administered to the subject.

15. The method of claim 1 comprising selecting a biological fluid processing protocol from a first protocol wherein saline is used to prime at least a portion of the fluid circuit and a second protocol wherein saline is not used to prime the fluid circuit.

16. A blood processing system comprising:
a) a disposable fluid processing circuit comprising a fluid processing device, a reservoir, access devices for establishing fluid communication with one or more containers of a processing fluid, a reservoir, an access device for establishing fluid communication with a fluid source and tubing defining a flow path for establishing flow communication between processing device, reservoir, said one or more containers, and said fluid source; and
b) a reusable hardware unit for receiving said fluid processing circuit in a predetermined relationship comprising a detector for detecting the presence of fluid within said liquid circuit and, a controller being in communication with said detector, said controller further comprising pre-programmed instructions for carrying out a selected blood processing protocol and configured to effect priming of said circuit according to the protocol selected, wherein said controller is further configured to effect introduction of an amount of a first solution from a first container of a processing solution and flow said first solution through a portion of said processing circuit and to introduce a further amount of said solution from said first container when the presence of liquid is detected by said detector, wherein said further amount is selected to deliver said first solution to a selected point of said flow path.

17. The system of claim 16 wherein said controller includes preprogrammed instructions for priming a portion of said circuit with a first solution and a portion of said circuit with a second solution.

18. The system of claim 17 wherein said controller includes preprogrammed instructions to carry out a blood processing protocol that includes administering said second solution as a replacement fluid.

19. The system of claim 17 further comprising a monitor for monitoring the amount of a solution used to prime said portion of said circuit.

20. The system of claim 19 wherein said monitor comprises a weight scale for a holding a container of said first solution.

21. The system of claim 19 wherein said monitor comprises a weight scale for a holding said reservoir.

22. The system of claim 16 wherein said controller is configured to introduce a fluid from a source other than said first container into said flow path and through at least a portion of said processing circuit that is different from the portion through which said first solution is flowed.

23. The system of claim 16 wherein said controller comprises pre-programmed instructions for carrying out two blood processing protocols and for priming said circuit according to the protocol selected.

24. The system of claim 23 wherein said two protocols include a first protocol wherein a replacement fluid is administered to a subject and a second protocol wherein no replacement fluid is administered to the subject.

Assignees

• Fenwal Inc

Inventors

• Planas Samantha M
• Patel Amit J
• Thill Melissa A
• Wegener Christopher
• Asma Elizabeth

Classifications

• A61M1/265

  inducing Taylor vortices · CPC title

• A61M1/3644 Primary

  Mode of operation · CPC title

• A61M1/0209

  Multiple bag systems for separating or storing blood components · CPC title

• A61M1/3643

  Priming, rinsing before or after use · CPC title

• A61M1/303

  having a reservoir for treated blood to be returned · CPC title