Molecular probes for imaging of myelin

Patent metadata

Field	Value
Publication number	US-9987379-B2
Application number	US-200913121742-A
Country	US
Kind code	B2
Filing date	Sep 30, 2009
Priority date	Sep 30, 2008
Publication date	Jun 5, 2018
Grant date	Jun 5, 2018

Abstract

A molecular probe for labeling myelin includes a fluorescent trans-stilbene derivative.

First claim

Having described the invention, the following is claimed:

1. A method of detecting myelin in vivo in an animal, the method comprising:
(i) administering to the animal a molecular probe including the general formula:

wherein R 1 and R 2 are each independently selected from the group consisting of H, NO 2 , NH 2 , NHCH 3 , N(CH 3 ) 2 , OH, OCH 3 , COOCH 3 , SH, SCH 3 , alkyl derivatives thereof, a halo group, a radiolabel, a chelating group, and a near infrared imaging group or a pharmaceutically acceptable salt thereof;
(ii) detecting the molecular probe in the animal using an in vivo imaging modality to determine myelinated regions in the animal, wherein the detected molecular probe is indicative of myelinated regions of the animal.

2. The method of claim 1 , the in vivo imaging modality comprising a Positron Emission Tomography (PET) imaging modality.

3. The method of claim 1 , the in vivo imaging modality comprising a micro Positron Emission Tomography (microPET) imaging modality.

4. The method of claim 1 , further comprising the step of administering the molecular probe to the animal parenterally.

5. The method of claim 1 , wherein the molecular probe further comprises a radiolabel.

6. The method of claim 5 , the radiolabel including a 3 H, 125 I, 11 C, or 18 F.

7. The method of claim 1 , wherein the molecular probe further comprises a chelating group or a near infrared imaging group.

8. The method of claim 1 , wherein R 1 and R 2 are amines or alkyl derivatives thereof.

9. The method of claim 1 , wherein at least one of R 1 or R 2 is an amine or alkyl derivative thereof.

Assignees

• Wang Yanming
• Wu Chunying
• Univ Case Western Reserve

Inventors

• Wang Yanming
• Wu Chunying

Classifications

• G01N2800/285

  Demyelinating diseases; Multipel sclerosis · CPC title

• A61K49/0021

  the fluorescent group being a small organic molecule · CPC title

• G01N33/92

  involving lipids, e.g. cholesterol {, lipoproteins, or their receptors (steroid hormones G01N33/743)} · CPC title

• A61K51/04

  Organic compounds · CPC title

• A61K49/10

  Organic compounds · CPC title