Blackberry extract

Patent metadata

Field	Value
Publication number	US-9987217-B2
Application number	US-62975305-A
Country	US
Kind code	B2
Filing date	Jun 16, 2005
Priority date	Jun 18, 2004
Publication date	Jun 5, 2018
Grant date	Jun 5, 2018

Abstract

The invention concerns a blackberry leaf extract and its uses, in particular to slow down skin aging, to treat the oral and pharyngeal cavity, and there in particular to prevent and slow down periodontitis and the excessive degradation of the periodontal connective tissue as well as damage to the teeth caused by matrix metalloproteinases.

First claim

The invention claimed is:

1. A product selected from the group consisting of a gel, oil-in-water emulsion, water-in-oil emulsion, a multiple emulsion, capsule, tablet, lotion, hypodispersion gel, chewing gum, tooth gel, and dental care chewing gum, wherein the product comprises a preparation for inhibiting metalloproteinase(s) MMP-1 and/or MMP-9 consisting essentially of an effective amount of a Rubus fruticosus leaf extract, wherein the Rubus fruticosus leaf extract is in solid form and is obtained by:
a) adding an aqueous extractant containing water and an alcohol selected from the group consisting of methanol, ethanol, n-propanol, iso-propanol, where the ratio of alcohol to water is 2:8 to 8:2 to dried Rubus fructicosus leaves;
b) extracting the dried Rubus fruticosus leaves with the extractant at a temperature of from 60° C. to 100° C. for a period of from 1 to 6 hours to obtain an extract;
c) adding a pharmaceutically acceptable solid support, or a cosmetically acceptable solid support selected from the group consisting of (i) powdered maltrodextrin, lactose, silicon dioxide, glucose and a combination thereof, or (ii) starches, degraded starches, chemically or physically modified starches, modified celluloses, gum arabic, gum ghatti, tragacanth gum, karaya, carrageenan, pullulan, curdlan, xanthan gum, gellan gum, guar gum, locust bean gum, alginates, agar, pectin, inulin and a combination thereof to said extract to obtain a mixture; and,
d) drying the mixture to provide a residual content of extractant of at most 5 wt. %, relative to the total weight of the extract obtained in step b) to obtain the solid Rubus fruticosus leaf extract.

2. The product of claim 1 wherein the alcohol is ethanol.

3. The product of claim 1 wherein the extractant contains a proportion of at least 20 wt. % of the alcohol.

4. The product of claim 1 , wherein the extractant and water are present in a ratio of from 3:7 to 7:3.

5. The product of claim 1 , wherein the drying step d) is spray-drying the extract of step (b) with the solid support of step (d) to form a powder.

6. A method of treating or reducing periodontitis or dental caries in a patient in need thereof consisting of orally administering to said patient an effective amount of an oral hygiene preparation selected from the group consisting of a tooth gel, chewing gum, or dental care chewing gum comprising 0.00001 wt. % to 20 wt. % of a Rubus fruticosus leaf extract in solid form by contacting the oral mucosa and teeth of the patient with the tooth gel, chewing gum, or dental care chewing gum in an amount effective to inhibit MMP-1 and MMP-9 activity in the oral mucosa and on the surface of the teeth, wherein the Rubus fruticosus leaf extract is obtained by:
a) adding an aqueous extractant containing water and an alcohol: selected from the group consisting of methanol, ethanol, n-propanol, iso-propanol, where the ratio of alcohol to water is 2:8 to 8:2 to dried Rubus fruticosus leaves;
b) extracting the dried Rubus fruticosus leaves with the extractant at a temperature of from 60° C. to 100° C. for a period of from 1 to 6 hours to obtain an extract;
c) adding a pharmaceutically acceptable solid support, or a cosmetically acceptable solid support selected from the group consisting of (i) powdered maltrodextrin, lactose, silicon dioxide; glucose and mixtures thereof or (ii) starches, degraded starches, chemically or physically modified starches, modified celluloses, gum arabic, gum ghatti, tragacanth gum, karaya, carrageenan, pullulan, curdlan, xanthan gum, gellan gum, guar gum, locust bean gum, alginates, agar, pectin, inulin and a combination thereof to said extract to obtain a mixture; and,
d) drying the mixture, to provide a residual content of extractant of at most 5 wt. %, relative to the total weight of the extract obtained in step b) to obtain the solid Rubus fruticosus leaf extract.

7. The method of claim 6 , wherein the preparation is selected from the group consisting of a toothgel, a chewing gum and a dental care chewing gum and said method comprising contacting oral mucosa and teeth with the toothgel, chewing gum or dental care chewing gum to inhibit periodontitis and damage to teeth.

Assignees

• Herrmann Martina
• Joppe Holger
• Franke Helge
• Vielhaber Gabriele
• Symrise Ag

Inventors

• Herrmann Martina
• Joppe Holger
• Franke Helge
• Vielhaber Gabriele

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61K2800/782

  Enzyme inhibitors; Enzyme antagonists · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title