Stimulus induced rotary saturation for magnetic resonance functional imaging

Patent metadata

Field	Value
Publication number	US-9983282-B2
Application number	US-94406207-A
Country	US
Kind code	B2
Filing date	Nov 21, 2007
Priority date	Nov 22, 2006
Publication date	May 29, 2018
Grant date	May 29, 2018

Abstract

Spin-lock T 1ρ -weighted images of a subject are acquired and processed to produce an image that is indicative of bioelectromagnetic activity in the subject. A spin-lock RF field B 1ρ is produced such that the Larmor frequency in the rotating frame corresponds to the expected frequency of the bioelectromagnetic activity. As a result, the magnetic field fluctuations generated by the bioelectromagnetic currents shorten the T 1ρ of the surrounding tissue, creating a contrast mechanism that is seen as a reduced MR signal in the T 1ρ -weighted image that is produced.

First claim

The invention claimed is:

1. A method for producing an image of bioelectromagnetic activity in a subject with a magnetic resonance imaging (MRI) system, the steps comprising:
a) acquiring T 1ρ -weighted image data from the subject using a pulse sequence that directs the MRI system to perform a spin-lock preparatory pulse sequence prior to acquiring nuclear magnetic resonance (NMR) image data, wherein the spin-lock preparatory pulse sequence includes applying a spin-lock radio frequency (RF) field, B 1ρ , that establishes a spin-lock condition in transverse spin magnetization such that transverse spin magnetization in the spin-lock condition is rotated by bioelectromagnetic fields directly produced by neuronal activity in the subject;
b) reconstructing an image with the acquired T 1ρ -weighted image data; and
c) analyzing image signals in the T 1ρ -weighted image to detect locations of neuronal activity in the subject.

2. The method as recited in claim 1 in which a magnitude of the spin-lock RF field, B 1ρ , is set to establish a Larmor frequency in a rotating frame of transverse magnetization that is substantially similar to a frequency of magnetic field fluctuations produced by the bioelectromagnetic field produced by neuronal activity in the subject.

3. The method as recited in claim 2 in which the Larmor frequency in the rotating frame is less than 100 Hz.

4. The method as recited in claim 1 in which the spin-lock preparatory pulse sequence includes:
a first RF excitation pulse that tips longitudinal spin magnetization to a transverse plane prior to establishing the spin-lock condition with the spin-lock RF field, B 1ρ ; and
a second RF excitation pulse that tips the transverse spin magnetization back to longitudinal spin magnetization after the established spin-lock condition.

5. The method as recited in claim 4 in which an imaging pulse sequence is performed by the MRI system after the second RF excitation pulse.

6. The method as recited in claim 5 in which the imaging pulse sequence is an echo planar imaging (EPI) pulse sequence.

7. The method as recited in claim 5 in which the spin-lock preparatory pulse sequence also includes a gradient pulse that dephases transverse magnetization that remains after application of the second RF excitation pulse.

8. The method as recited in claim 1 in which the spin-lock RF field, B 1ρ , is applied for a time period sufficiently long to enable the bioelectromagnetic fields produced by neuronal activity to alter the transverse spin magnetization in the spin-lock condition, the altered transverse spin magnetization providing a contrast mechanism for detecting the neuronal activity.

9. The method as recited in claim 1 in which the spin-lock preparatory pulse sequence includes:
a first RF excitation pulse that produces transverse spin magnetization by tipping longitudinal spin magnetization to a transverse plane prior to establishing the spin-lock condition with the spin-lock RF field, B 1ρ ; and
an imaging pulse sequence that reads out an NMR signal produced by the transverse spin magnetization after the established spin-lock condition.

10. The method as recited in claim 9 in which the spin-lock RF field, B 1ρ , is applied for a time period sufficiently long to enable the bioelectromagnetic fields produced by neuronal activity to alter the transverse spin magnetization in the spin-lock condition, the altered transverse spin magnetization providing a contrast mechanism for detecting the neuronal activity.

11. The method as recited in claim 1 in which step c) includes analyzing the image signals in the T 1ρ -weighted image to identify locations where the T 1ρ -weighted image signal is reduced in order to detect locations of neuronal activity in the subject.

Assignees

• Wald Lawrence L
• Witzel Thomas
• Rosen Bruce R
• Massachusetts Gen Hospital

Inventors

• Wald Lawrence L
• Witzel Thomas
• Rosen Bruce R

Classifications

• G01R33/48 Primary

  NMR imaging systems · CPC title

• G01R33/5602

  by filtering or weighting based on different relaxation times within the sample, e.g. T1 weighting using an inversion pulse · CPC title

• G01R33/4806

  Functional imaging of brain activation · CPC title