Fiber and column for protein adsorption

Patent metadata

Field	Value
Publication number	US-9982369-B2
Application number	US-201515511185-A
Country	US
Kind code	B2
Filing date	Sep 16, 2015
Priority date	Sep 16, 2014
Publication date	May 29, 2018
Grant date	May 29, 2018

Abstract

A fiber for protein adsorption has a water absorption percentage of 1 to 50%, and the fiber includes a polymer containing as repeat units an aromatic hydrocarbon or a derivative thereof, wherein part of aromatic rings contained in the repeat units are cross-linked through a structure represented by Formula (I). A column for protein adsorption uses the fibers. A in Formula (I) is selected from an alkyl aliphatic group, phenyl aromatic group and amino group.

First claim

The invention claimed is:

1. A fiber for protein adsorption,
wherein said fiber has a water absorption percentage of 1 to 50%; and
said fiber comprises a polymer containing as repeat units an aromatic hydrocarbon and/or a derivative thereof, wherein part of aromatic rings contained in said repeat units are cross-linked through a structure represented by Formula (I):

wherein A is selected from the group consisting of an aliphatic group, aromatic group and amino group, and each wavy line represents a position bound to an aromatic ring.

2. The fiber according to claim 1 , wherein, in said formula, A represents Formula (A-1), (A-2), or (A-3):

wherein R 1 to R 5 each independently represent a hydrogen atom or a C 1 -C 10 hydrocarbon group, and each wavy line represents a binding position.

3. The fiber according to claim 1 , wherein said polymer is a polymer selected from the group consisting of polystyrene, polysulfone, and derivatives thereof.

4. The fiber according to claim 1 , wherein the single yarn diameter of said fiber is 0.1 to 1000 μm.

5. The fiber according to claim 1 , wherein a number of aromatic rings in Formula (I) with respect to a total number of aromatic rings contained in said cross-linked polymer is 4 to 70%.

6. The fiber according to claim 1 , adapted for cytokine adsorption.

7. A column for protein adsorption comprising, as an adsorptive carrier, the fiber according to claim 1 .

8. The fiber according to claim 2 , wherein said polymer is a polymer selected from the group consisting of polystyrene, polysulfone, and derivatives thereof.

9. The fiber according to claim 2 , wherein the single yarn diameter of said fiber is 0.1 to 1000 μm.

10. The fiber according to claim 3 , wherein the single yarn diameter of said fiber is 0.1 to 1000 μm.

11. The fiber according to claim 2 , wherein a number of aromatic rings in Formula (I) with respect to a total number of aromatic rings contained in said cross-linked polymer is 4 to 70%.

12. The fiber according to claim 3 , wherein a number of aromatic rings in Formula (I) with respect to a total number of aromatic rings contained in said cross-linked polymer is 4 to 70%.

13. The fiber according to claim 4 , wherein a number of aromatic rings in Formula (I) with respect to a total number of aromatic rings contained in said cross-linked polymer is 4 to 70%.

14. The fiber according to claim 2 , adapted for cytokine adsorption.

15. The fiber according to claim 3 , adapted for cytokine adsorption.

16. The fiber according to claim 4 , adapted for cytokine adsorption.

17. The fiber according to claim 5 , adapted for cytokine adsorption.

18. A column for protein adsorption comprising, as an adsorptive carrier, the fiber according to claim 2 .

19. A column for protein adsorption comprising, as an adsorptive carrier, the fiber according to claim 3 .

20. A column for protein adsorption comprising, as an adsorptive carrier, the fiber according to claim 4 .

Assignees

• Toray Industries

Inventors

• Kasuya Junichi
• Tomita Naotoshi
• Ueno Yoshiyuki

Classifications

• D06M2400/01

  Creating covalent bondings between the treating agent and the fibre · CPC title

• C08L2203/12

  used for fibers · CPC title

• C08L2203/02

  for biomedical use · CPC title

• B01J20/262

  obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation (macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds per se C08G) · CPC title

• B01J20/261

  obtained by reactions only involving carbon to carbon unsaturated bonds (macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F) · CPC title