Methods and compositions related to inhibition of viral entry
US-2016354428-A1 · Dec 8, 2016 · US
Cyclin based inhibitors of CDK2 and CDK4
US9982015B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9982015-B2 |
| Application number | US-201615192247-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 24, 2016 |
| Priority date | Mar 27, 2012 |
| Publication date | May 29, 2018 |
| Grant date | May 29, 2018 |
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Abstract
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Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.
First claim
Opening claim text (preview).
What is claimed is: 1. A synthetic CDK/cyclin inhibitor that inhibits interaction of a complex formed between a first CDK protein and a first cyclin protein with a substrate of the complex, the synthetic CDK/cyclin inhibitor comprising a peptide sequence and a capping group bonded to the N-terminus of the peptide sequence, the capping group comprising a substituted benzoic acid, the peptide sequence comprising Arg-βhomoLeu-3-thienylalanine, the capping group having the following structure: 2. The synthetic CDK/cyclin inhibitor of claim 1 , further comprising a capping group bonded to the C-terminus of the peptide sequence. 3. The synthetic CDK/cyclin inhibitor of claim 2 , wherein the capping group bonded to the C-terminus is 2-amino-N-ethyl-4-methyl-N-(3-phenylpropyl)pentanam ide. 4. The synthetic CDK/cyclin inhibitor of claim 2 , wherein the capping group bonded to the C-terminus is an ethyl phenylethan-amine, a phenylpropylamine, or an ethyl phenylpropyl amine. 5. The synthetic CDK/cyclin inhibitor of claim 2 , wherein the capping group bonded to the C-terminus includes phenylalanine, histidine, βHomophenylalanine, or βHomo-histidine.
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Classifications
Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR (cell cycle dependent kinases C12N9/12) · CPC title
- C07K5/1024Primary
with the first amino acid being heterocyclic · CPC title
and aromatic or cycloaliphatic · CPC title
the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu · CPC title
Arg-amino acid · CPC title
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- What does patent US9982015B2 cover?
- Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including can…
- Who is the assignee on this patent?
- Univ South Carolina
- What technology area does this patent fall under?
- Primary CPC classification C07K5/1024. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 29 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).