Microfluidic mixing device

Patent metadata

Field	Value
Publication number	US-9981265-B2
Application number	US-201615134300-A
Country	US
Kind code	B2
Filing date	Apr 20, 2016
Priority date	Jun 24, 2013
Publication date	May 29, 2018
Grant date	May 29, 2018

Abstract

A microfluidic mixing device comprises a main channel and a number of secondary channels extending from a portion of the main channel and entering another portion of the main channel. A number of actuators are located in the secondary channels to pump fluids through the secondary channels. A microfluidic mixing system comprises a microfluidic mixing device. The microfluidic mixing device comprises a main fluid mixing channel, a number of main channel actuators to pump fluid through the main fluid mixing channel, a number of secondary channels fluidly coupled to the main fluid mixing channel, and a number of secondary channel actuators to pump fluids through the secondary channels. The microfluidic mixing device also comprises a fluid source, and a control device to provide fluids from the fluid source to the microfluidic mixing device and activate the main channel actuators and secondary channel actuators.

First claim

What is claimed is:

1. A microfluidic mixing device comprising:
a main channel;
a number of secondary channels extending from the main channel; and
a number of actuators located in the secondary channels to pump fluids within the secondary channels,
wherein at least one of the secondary channels comprises a number of I-shaped secondary channels, and
wherein a number of the actuators located within the I-shaped secondary channels are configured to produce a flood and drain flow into and out of the I-shaped secondary channels and are configured to create a number of transverse flows within the main channel.

2. The microfluidic mixing device of claim 1 , wherein at least two I-shaped secondary channels extend from the main channel.

3. The microfluidic mixing device of claim 2 , wherein the at least two I-shaped secondary channels extend from the main channel on a common side of the main channel.

4. The microfluidic mixing device of claim 2 , wherein the at least two I-shaped secondary channels extend from the main channel on opposite sides from one another with respect to a longitudinal axis of the main channel.

5. The microfluidic mixing device of claim 3 , wherein the at least two I-shaped secondary channels are located offset from each other on the opposite sides of the main channel.

6. The microfluidic mixing device of claim 1 , wherein the actuators are located axis-asymmetrically within the I-shaped secondary channels to cause fluid displacements that mix the fluids as they flow into and out of the I-shaped secondary channels.

7. The microfluidic mixing device of claim 1 , comprising a main channel actuator located in the main channel to cause a unidirectional fluid flow through the main channel.

8. The microfluidic mixing device of claim 1 , wherein the actuators comprise an inertial pump.

9. A microfluidic mixing system comprising:
a main fluid mixing channel;
a number of I-shaped secondary channels extending from the main channel; and
a number of actuators located in the secondary channels to pump fluids within the secondary channels,
wherein at least one of the secondary channels comprises a number of I-shaped secondary channels, and
wherein the I-shaped secondary channels are configured to produce a flood and drain flow into and out of the I-shaped secondary channels and are configured to create a number of transverse flows within the main channel.

10. The microfluidic mixing system of claim 9 , wherein the actuators are located axis-asymmetrically within the I-shaped secondary channels to cause fluid displacements that mix the fluids as they flow into and out of the I-shaped secondary channels.

11. The microfluidic mixing system of claim 9 , comprising a main channel actuator located in the main channel to cause a unidirectional fluid flow through the main channel.

12. The microfluidic mixing system of claim 9 , comprising:
a fluid source; and
a control device to:
provide fluids from the fluid source to the microfluidic mixing device; and
activate the main channel actuators and secondary channel actuators.

13. The microfluidic mixing system of claim 9 , comprising:
a fluid inlet chamber to pass fluids into the main fluid mixing channel of the microfluidic mixing device; and
a fluid outlet chamber to receive the mixed fluids from the main fluid mixing channel of the microfluidic mixing device.

14. The microfluidic mixing system of claim 11 , wherein the secondary channel actuators and main channel actuators comprise thermal resistors, piezo elements, deflective membrane elements activated by electrical forces, deflective membrane elements activated by magnetic forces, deflective membrane elements activated by mechanical forces, a mechanical transducer, an acoustic transducer, an ultrasonic transducer, a dielectrophoretic transducer, an electrokinetic timepulse transducer, a pressure perturbation transducer, magnetic transducers, or a combination thereof.

15. The microfluidic mixing system of claim 12 , wherein the control device controls the sequence and timing of activation of the actuators within the I-shaped secondary channels.

16. The microfluidic mixing device of claim 1 , further comprising:
a non-transitory computer readable storage medium comprising computer usable program code embodied therewith, and a processor to execute the program code to:
activate a number of the secondary channel actuators to pump fluids through the secondary channels.

17. The microfluidic mixing device of claim 16 , comprising computer usable program code to, when executed by the processor, receive data from a host device, the data representing executable instructions to be executed by the processor to control the activation of a number of main channel actuators and the secondary channel actuators.

18. The microfluidic mixing device of claim 16 , wherein the actuators located within the I-shaped secondary channels are bi-directional actuators, and wherein the computer program product comprises computer usable program code to, when executed by the processor, activate the bi-directional actuators to pump fluid in a first direction to flood the I-shaped secondary channels and activate the actuators located within the I-shaped secondary channels to pump fluid in a second direction to drain the I-shaped secondary channels.

19. The microfluidic mixing device of claim 16 , wherein at least two I-shaped secondary channels extend from the main channel and wherein the computer program product comprises computer usable program code to, when executed by the processor, activate the actuators within a first I-shaped secondary channels at a different time respect to second I-shaped secondary channel.

20. The microfluidic mixing device of claim 16 , comprising computer usable program code to, when executed by the processor, activate a fluid source to introduce a number of fluids into the main channel of a microfluidic mixing device.

Assignees

• Hewlett Packard Development Co

Inventors

• Govyadinov Alexander
• Kornilovich Pavel
• Torniainen Erik D
• Markel David P

Classifications

• B01L3/50273 Primary

  characterised by the means or forces applied to move the fluids · CPC title

• F01D3/00

  Machines or engines with axial-thrust balancing effected by working-fluid · CPC title

• B01L2400/0439

  ultrasonic vibrations, vibrating piezo elements · CPC title

• B01L2400/0478

  pistons · CPC title

• B01F5/10

  Operations & Transport · mapped topic