Method of reducing MACE in diabetic patients subsequent to stent placement
US-9217042-B2 · Dec 22, 2015 · US
Anti-thrombogenic grafts
US9981066B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9981066-B2 |
| Application number | US-201414783897-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 19, 2014 |
| Priority date | May 20, 2013 |
| Publication date | May 29, 2018 |
| Grant date | May 29, 2018 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The present invention provides anti-thrombogenic compositions, including anti-thrombogenic vascular grafts. In certain embodiments, the compositions comprise decellularized tissue coated with an anti-thrombogenic coating. The present invention also provides methods of preparing anti-thrombogenic compositions and methods of treatment comprising implanting the anti-thrombogenic compositions into a subject in need thereof.
First claim
Opening claim text (preview).
What is claimed: 1. A composition comprising a substrate having at least one surface coated with an anti-thrombogenic coating, wherein the anti-thrombogenic coating comprises a first layer comprising a hydrogel and a second layer comprising an anti-coagulant, wherein the first layer contacts the substrate, and wherein the substrate is decellularized tissue. 2. The composition of claim 1 , wherein the first layer comprises hyaluronic acid. 3. The composition of claim 2 , wherein the hyaluronic acid is thiol-modified hyaluronic acid. 4. The composition of claim 1 , wherein the first layer is crosslinked to the at least one surface of the substrate. 5. The composition of claim 1 , wherein the second layer is crosslinked to the first layer. 6. The composition of claim 5 , wherein the second layer comprises heparin. 7. The composition of claim 1 , wherein the decellularized tissue is a decellularized blood vessel having a luminal surface, and wherein the anti-thrombogenic coating is coated on the luminal surface of the decellularized blood vessel.
Assignees
Inventors
Classifications
Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof · CPC title
Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates · CPC title
Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title
Hydrogels or hydrocolloids · CPC title
having two or more layers · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9981066B2 cover?
- The present invention provides anti-thrombogenic compositions, including anti-thrombogenic vascular grafts. In certain embodiments, the compositions comprise decellularized tissue coated with an anti-thrombogenic coating. The present invention also provides methods of preparing anti-thrombogenic compositions and methods of treatment comprising implanting the anti-thrombogenic compositions into …
- Who is the assignee on this patent?
- Univ Yale
- What technology area does this patent fall under?
- Primary CPC classification A61L27/507. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 29 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).