Cosmetic compositions comprising hyaluronan biosynthesis promoting agents

Patent metadata

Field	Value
Publication number	US-9980894-B2
Application number	US-201214408117-A
Country	US
Kind code	B2
Filing date	Jun 15, 2012
Priority date	Jun 15, 2012
Publication date	May 29, 2018
Grant date	May 29, 2018

Abstract

Suggested is a cosmetic composition, comprising compounds of formula (I) wherein R and R′ independently of one another denote hydrogen, hydroxyl, a linear or branched OC 1 -C 4 -alkyl group, or optionally R and R′ form together a methylenedioxy group resulting in a 3,4-methylendioxyphenyl residue and R″ denotes a linear or branched C 1 -C 9 alkyl group or A, wherein A denotes formula (II) with X, Y and Z being independently of one another hydrogen, hydroxyl, an linear or branched C 1 -C 4 -alkyl group, or a linear or branched OC 1 -C 4 -alkyl group.

First claim

The invention claimed is:

1. A cosmetic composition, comprising active compounds of formula (I)

wherein
R and R′ independently of one another denote, hydrogen, hydroxyl, a linear or branched OC 1 -C 4 -alkyl group, or optionally R and R′ form together a methylenedioxy group resulting in a 3,4-methylendioxyphenyl residue and R″ denotes a linear or branched C 1 -C 9 alkyl group or A, wherein A denotes

with X, Y and Z being independently of one another hydrogen, hydroxyl, an linear or branched C 1 -C 4 -alkyl group, or a linear or branched OC 1 -C 4 -alkyl group, and
wherein the actives are present in amounts of 0.000005 to 0.00001 percent by weight based on the total weight of the composition.

2. The composition of claim 1 , wherein the active is 4-(3,4-methylendioxyphenyl)-2-butanone (Cassione) according to formula (II)

3. The cosmetic composition of claim 1 , comprising
(a) at least ore active of formula (I),
(b) at least one cosmetic additive, and
(c) at least one cosmetically acceptable carrier.

4. The composition of claim 3 , wherein said cosmetic additives are selected from the group consisting of antioxidants, primary or secondary sun protection factors, matrix-metalloproteinase (MMP) inhibitors, skin-moisturizing agents, glycosaminoglycans (GAGs) and further substances stimulating the synthesis of glycosaminoglycans, anti-inflammatory agents and TRVP1 antagonists.

5. The composition of claim 3 for topical application.

6. The composition of claim 3 for oral administration.

7. A pharmaceutical or dermatological composition, comprising active compounds of formula (I)

wherein
R and R′ independently of one another denote hydrogen, hydroxyl, a linear or branched OC 1 -C 4 -alkyl group, or optionally R and R′ form together a methylenedioxy group resulting in a 3,4-methylendioxyphenyl residue and R″ denotes a linear or branched C 1 -C 9 alkyl group or A, wherein A denotes

with X, Y and Z being independently of one another hydrogen, hydroxyl, an linear or branched C 1 -C 4 -alkyl group, or a linear or branched OC 1 -C 4 -alkyl group for stimulating biosynthesis of hyaluronan in human tissue or skin or hair.

8. The composition of claim 7 wherein the actives are present in amounts of 0.000005 to 0.00001 percent by weight based on the total weight of the composition.

Assignees

• Herrmann Martina
• Schmaus Gerhardd
• Symrise Ag

Inventors

• Herrmann Martina
• Schmaus Gerhardd

Classifications

• A61Q19/007

  Preparations for dry skin · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61K8/4973 Primary

  with oxygen as the only hetero atom · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title