Systems and methods for signal processing in molecular imaging
US-2024013454-A1 · Jan 11, 2024 · US
US9980686B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9980686-B2 |
| Application number | US-201414905890-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 4, 2014 |
| Priority date | Jul 23, 2013 |
| Publication date | May 29, 2018 |
| Grant date | May 29, 2018 |
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An imaging system ( 100 ) includes a detector array ( 110 ) that detects radiation traversing an examination region. The detector array includes at least a set of non-spectral detectors ( 112 ) that detects a first sub-portion of the radiation traversing the examination region and generates first signals indicative thereof. The detector array further includes at least a set of spectral detectors ( 114 ) that detects a second sub-portion of the radiation traversing the examination region and generates second signals indicative thereof. The imaging system further includes a reconstructor ( 120 ) that processes the first and second signals, generating volumetric image data.
Opening claim text (preview).
The invention claimed is: 1. An imaging system, comprising: a detector array that detects x-ray radiation traversing an examination region, the detector array, including: at least a set of spectral detectors that detect a first sub-portion of the radiation traversing the examination region and generates first signals indicative thereof; a first inner region relative to the center of the detector array populated with a first portion of the set of spectral detectors and a first outer region relative to the first inner region populated with a second portion of the set of spectral detectors; at least a set of non-spectral detectors that detects a second sub-portion of the radiation traversing the examination region and generates second signals indicative thereof; and a second outer region relative to the first outer region populated with the set of non-spectral detectors; and a reconstructor that processes the first and second signals, generating volumetric image data, the reconstructor comprising: a spectral reconstructor that processes the first and second signals with a spectral reconstruction algorithm thereby reconstructing spectral volumetric image data, wherein the spectral reconstruction algorithm is an iterative statistical reconstruction algorithm that includes a material decomposition and a log likelihood reconstruction. 2. The system of claim 1 , a spectral detector of the set of spectral detectors, comprising: at least a single scintillator layer; and at least two detector pixels, wherein the at least two detector pixels are optically side-mounted to the at least a single scintillator in a direction traverse to incident radiation. 3. The system of claim 1 , a spectral detector of the set of spectral detectors, comprising: at least two scintillator layers stacked one upon another; and at least two detector pixels wherein each of the at least two detector pixels is respectively optically side-mounted to a different one of the at least two scintillators in a direction traverse to incident radiation. 4. The system of claim 1 , a spectral detector of the set of spectral detectors, comprising: at least two stacked scintillator layers; and at least two detector pixels, wherein the stack of scintillator layers are disposed over the at least two detector pixels in a direction of incident radiation. 5. The system of claim 1 , the reconstructor, further comprising: a non-spectral reconstructor that combines the first signals, thereby creating non-spectral signals and processes the second signals and the created non-spectral signals with a non-spectral reconstruction algorithm to reconstruct the volumetric image data. 6. The system of claim 1 , wherein the spectral reconstruction algorithm includes a data term with a non-spectral data component and a spectral data component and a regularization term, each term being a function of two or more basis material, and the spectral reconstructor maximizes a likelihood that an intermediate image fits a measured data given a noise model and regularization factor. 7. The system of claim 1 , wherein the reconstructor is configured to process the first and second signals and generate spectral volumetric image data based on the following: L S ( B 1 ,B 2 , . . . ,B N )= L 1 ( B 1 ,B 2 , . . . ,B N )+α L 2 ( B 1 ,B 2 , . . . ,B N )+β R ( B 1 ,B 2 , . . . ,B N ), where L S is a negative log likelihood for a spectral reconstruction, R represents a roughness penalty term that penalizes noise in the reconstructed image β represents a regularization term that controls a strength of the penalty, α is a constant, B1, B2, . . . BN represents N basis materials, N is a positive integer, L1 is a negative log likelihood of projection data generated by the set of non-spectral detectors, and L2 a negative log likelihood of projection data generated by the set of spectral detectors, wherein L1 and L2 are defined over all basis material images and reflect a spectral sensitivity and a noise model of the detector array.
Inverse problem, i.e. transformations from projection space into object space · CPC title
Tomographic reconstruction from projections · CPC title
combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT · CPC title
Transmission computed tomography [CT] · CPC title
involving multiple energy imaging · CPC title
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