PatentsDB

Synzymes

US9976133B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9976133-B2
Application numberUS-201314406999-A
CountryUS
Kind codeB2
Filing dateJun 20, 2013
Priority dateJun 20, 2012
Publication dateMay 22, 2018
Grant dateMay 22, 2018

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

Novel synthetic catalytic structures or “synzymes,” e.g., synthetic polypeptides, with catalytic properties are provided. It is believed that these synthetic catalytic structures mimic some of the precise conformational changes necessary for catalytic activities seen in enzymes. The catalytic properties of these synthetic catalytic structures or synzymes can be further improved by the application of controlled external forces, e.g., electric fields.

First claim

Opening claim text (preview).

What is claimed is: 1. A synthetic polypeptide comprising an amino acid sequence selected from the group consisting of: (SEQ ID NO: 22) Gly-Ala-Phe-Cys-Phe-His-Ala-Asp; (SEQ ID NO: 23) Gly-Ala-Phe-Ser-Phe-His-Ala-Asp; (SEQ ID NO: 24) Asp-Phe-His-Phe-Cys-Ala-Gly-Asp; (SEQ ID NO: 25) Asp-Phe-His-Phe-Ser-Ala-Gly-Asp; (SEQ ID NO: 26) Gly-Gly-Ala-Ala-Cys-Ala-His-Ala-Asp; (SEQ ID NO: 27) Arg-Gly-Ala-Ala-Cys-Ala-His-Ala-Asp; (SEQ ID NO: 28) Arg-Gly-Ala-Ala-Ser-Ala-His-Ala-Asp; (SEQ ID NO: 29) Arg-Gly-Ala-Phe-Cys-Phe-His-Ala-Asp; (SEQ ID NO: 30) Lys-Gly-Ala-Phe-Cys-Phe-His-Ala-Asp; (SEQ ID NO: 31) Arg-Gly-Ala-Phe-Ser-Phe-His-Ala-Asp; (SEQ ID NO: 32) Lys-Gly-Ala-Phe-Ser-Phe-His-Ala-Asp; (SEQ ID NO: 33) Arg-Asp-Phe-His-Phe-Cys-Ala-Gly-Asp; (SEQ ID NO: 34) Arg-Asp-Phe-His-Phe-Ser-Ala-Gly-Asp; (SEQ ID NO: 36) Arg-Gly-His-Gly-Gly-Pro-Gly-Gly-His- Gly-Cys-Gly-Asp; and (SEQ ID NO: 37) Arg-Gly-Gly-His-Phe-Cys-Gly-Pro-Gly- His-Gly-His-Gly-Asp, and wherein the synthetic polypeptide is from 6 to 30 amino acids total in length. 2. The synthetic polypeptide of claim 1 , wherein the synthetic polypeptide comprises an amino acid sequence selected from the group consisting of: (SEQ ID NO: 26) Gly-Gly-Ala-Ala-Cys-Ala-His-Ala-Asp; (SEQ ID NO: 27) Arg-Gly-Ala-Ala-Cys-Ala-His-Ala-Asp; (SEQ ID NO: 28) Arg-Gly-Ala-Ala-Ser-Ala-His-Ala-Asp; (SEQ ID NO: 29) Arg-Gly-Ala-Phe-Cys-Phe-His-Ala-Asp; (SEQ ID NO: 30) Lys-Gly-Ala-Phe-Cys-Phe-His-Ala-Asp; (SEQ ID NO: 31) Arg-Gly-Ala-Phe-Ser-Phe-His-Ala-Asp; (SEQ ID NO: 32) Lys-Gly-Ala-Phe-Ser-Phe-His-Ala-Asp; (SEQ ID NO: 33) Arg-Asp-Phe-His-Phe-Cys-Ala-Gly-Asp; and (SEQ ID NO: 34) Arg-Asp-Phe-His-Phe-Ser-Ala-Gly-Asp, and wherein the synthetic polypeptide is from 9 to 15 amino acids total in length.

Assignees

Inventors

Classifications

  • G01N2333/95

    Proteinases, i.e. endopeptidases (3.4.21-3.4.99) · CPC title

  • C12N13/00Primary

    Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves · CPC title

  • C12Y304/22

    Cysteine endopeptidases (3.4.22) · CPC title

  • C07K7/08

    having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title

  • C07K7/06

    having 5 to 11 amino acids · CPC title

Patent family

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View patent family 49769703

External sources

Frequently asked questions

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What does patent US9976133B2 cover?
Novel synthetic catalytic structures or “synzymes,” e.g., synthetic polypeptides, with catalytic properties are provided. It is believed that these synthetic catalytic structures mimic some of the precise conformational changes necessary for catalytic activities seen in enzymes. The catalytic properties of these synthetic catalytic structures or synzymes can be further improved by the applicati…
Who is the assignee on this patent?
Univ California
What technology area does this patent fall under?
Primary CPC classification C12N13/00. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue May 22 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).