Aqueous gel

Patent metadata

Field	Value
Publication number	US-9976000-B2
Application number	US-201414535607-A
Country	US
Kind code	B2
Filing date	Nov 7, 2014
Priority date	May 12, 2012
Publication date	May 22, 2018
Grant date	May 22, 2018

Abstract

An aqueous gel that is prepared by gelling a polymer components, the polymer components containing polymer A, which is obtained by polymerizing a monomer component containing a betaine monomer represented by the formula (I):

wherein R 1 represents hydrogen atom or an alkyl group, R 2 represents an alkylene, arylene, aralkylene, —COOH— or —CONH— group; R 3 and R 4 represent an alkyl group, and R 5 represents an alkylene group, and a polymer B, which is obtained by polymerizing a monomer component containing an acidic monomer represented by the formula (II):

wherein R 1 represents hydrogen atom or an alkyl group; R 6 represents an optionally neutralized sulfonate group, an optionally neutralized phosphate group, or an alkyl, aryl, aralkyl, carboxyl or amino group carrying an optionally neutralized sulfonate group or an optionally neutralized phosphate group.

First claim

The invention claimed is:

1. An aqueous gel prepared by gelling a polymer composition comprising a polymer A prepared by carrying out the polymerization of a monomer composition comprising a betaine monomer represented by the formula (I):

wherein R 1 is hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may have hydroxyl group or a halogen atom; R 2 is an alkylene group having 1 to 6 carbon atoms which may have hydroxyl group, an arylene group having 6 to 12 carbon atoms, an aralkylene group having 7 to 12 carbon atoms, —COOH— group or —CONH— group; each of R 3 and R 4 is independently an alkyl group having 1 to 18 carbon atoms; and R 5 is an alkylene group having 1 to 8 carbon atoms,
and a polymer B prepared by carrying out the polymerization of a monomer composition comprising an acidic monomer represented by the formula (II):

wherein R 1 is hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may have hydroxyl group or a halogen atom; R 6 is sulfonic acid group or a neutralized group thereof; phosphoric acid group or a neutralized group thereof; an alkyl group having 1 to 6 carbon atoms having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof, which may have a halogen atom; an aryl group having 6 to 12 carbon atoms having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof; an aralkyl group having 7 to 12 carbon atoms having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof; carboxyl group having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof; or an amino group having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof.

2. The aqueous gel according to claim 1 , wherein in the betaine monomer represented by the formula (I), R 1 is hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may have hydroxyl group or a halogen atom; R 2 is —COO— group or —CONH— group; each of R 3 and R 4 is methyl group, respectively; and R 5 is methylene group.

3. The aqueous gel according to claim 1 , wherein the molar ratio of the functional group of the polymer A to the functional group of the polymer B is 0.5/1 to 1.5/1.

4. A process for producing an aqueous gel according to claim 1 , which comprises carrying out a solution polymerization of an aqueous solution of a monomer composition comprising an acidic monomer to give polymer B, mixing the resulting polymer B with an aqueous solution of a monomer composition comprising a betaine monomer to form a homogeneous mixture, and carrying out a solution polymerization of the resulting mixture to prepare a polymer A; or carrying out a solution-polymerization of an aqueous solution of a monomer composition comprising a betaine monomer to give a polymer A, mixing the resulting polymer A with a monomer composition comprising an acidic monomer to form a homogeneous mixture, and carrying out the solution-polymerization of the resulting mixture to prepare a polymer B.

5. A medical device comprising aqueous gel prepared by gelling a polymer composition comprising a polymer A prepared by carrying out the polymerization of a monomer composition comprising a betaine monomer represented by the formula (I):

wherein R 1 is hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may have hydroxyl group or a halogen atom; R 2 is an alkylene group having 1 to 6 carbon atoms which may have hydroxyl group, an arylene group having 6 to 12 carbon atoms, an aralkylene group having 7 to 12 carbon atoms, —COOH— group or —CONH— group; each of R 3 and R 4 is independently an alkyl group having 1 to 18 carbon atoms; and R 5 is an alkylene group having 1 to 8 carbon atoms,
and a polymer B prepared by carrying out the polymerization of a monomer composition comprising an acidic monomer represented by the formula (II):

wherein R 1 is hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may have hydroxyl group or a halogen atom; R 6 is sulfonic acid group or a neutralized group thereof; phosphoric acid group or a neutralized group thereof; an alkyl group having 1 to 6 carbon atoms having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof, which may have a halogen atom; an aryl group having 6 to 12 carbon atoms having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof; an aralkyl group having 7 to 12 carbon atoms having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof; carboxyl group having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof; or an amino group having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof.

6. A cosmetic composition comprising aqueous gel prepared by gelling a polymer composition comprising a polymer A prepared by carrying out the polymerization of a monomer composition comprising a betaine monomer represented by the formula (I):

wherein R 1 is hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may have hydroxyl group or a halogen atom; R 2 is an alkylene group having 1 to 6 carbon atoms which may have hydroxyl group, an arylene group having 6 to 12 carbon atoms, an aralkylene group having 7 to 12 carbon atoms, —COOH— group or —CONH— group; each of R 3 and R 4 is independently an alkyl group having 1 to 18 carbon atoms; and R 5 is an alkylene group having 1 to 8 carbon atoms,
and a polymer B prepared by carrying out the polymerization of a monomer composition comprising an acidic monomer represented by the formula (II):

wherein R 1 is hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may have hydroxyl group or a halogen atom; R 6 is sulfonic acid group or a neutralized group thereof; phosphoric acid group or a neutralized group thereof; an alkyl group having 1 to 6 carbon atoms having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof, which may have a halogen atom; an aryl group having 6 to 12 carbon atoms having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof; an aralkyl group having 7 to 12 carbon atoms having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof; carboxyl group having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof; or an amino group having sulfonic acid group or a neutralized group thereof, or phosphoric acid group or a neutralized group thereof.

7. A toiletry article comprising aqueous gel prepared by gelling a polymer composition comprising a polymer A prepared by carrying out the polymerization of a monomer composition comprising a betaine monomer represented by t

Assignees

• Univ Hokkaido Nat Univ Corp
• Osaka Organic Chemical Ind Ltd
• National Univ Corp Hokkaido Univ
• Osaka Organic Chemical Ind Ltd

Inventors

• Gong Jian Ping
• Kurokawa Takayuki
• Yin Haiyan
• AKASAKI Taigo
• Saruwatari Yoshiyuki

Classifications

• C08J3/075 Primary

  Macromolecular gels · CPC title

• C09D135/02

  Homopolymers or copolymers of esters (C09D135/06, C09D135/08 take precedence) · CPC title

• C09D151/003

  grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds (C09D151/04, C09D151/06 take precedence) · CPC title

• C08L2201/54

  Aqueous solutions or dispersions · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title