Modulators of sphingosine phosphate receptors

Patent metadata

Field	Value
Publication number	US-9975863-B2
Application number	US-201715713237-A
Country	US
Kind code	B2
Filing date	Sep 22, 2017
Priority date	May 14, 2008
Publication date	May 22, 2018
Grant date	May 22, 2018

Abstract

Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphingosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

First claim

What is claimed is:

1. A compound of Formula I-D:

or pharmaceutically acceptable salt thereof,
wherein
the compound is substituted with 0-5 J groups;
R 7 and R 8 are taken together to form ═O;
J is independently at each occurrence F, Cl, Br, I, OR′, OC(O)N(R′) 2 , CN, CF 3 , OCF 3 , CHF 2 , NO 2 , R′, ═O, ═S, methylenedioxy, ethylenedioxy, N(R′) 2 , N(R′)CH 2 CH 2 OR′, SR′, SOR′, SO 2 R′, SO 2 N(R′) 2 , SO 3 R′, C(O)R′, C(O)C(O)R′, C(O)CH 2 C(O)R′, C(S)R′, C(O)OR′, OC(O)R′, OC(O)OR′, C(O)N(R′) 2 , OC(O)N(R′) 2 , C(S)N(R′) 2 , (CH 2 ) 0-2 NHC(O)R′, (CH 2 ) 0-2 N(R′) 2 , (CH 2 ) 0-2 N(R′)N(R′) 2 , N(R′)N(R′)C(O)R′, N(R′)N(R′)C(O)OR′, N(R′)N(R′)CON(R′) 2 , N(R′)SO 2 R′, N(R′)SO 2 N(R′) 2 , N(R′)C(O)OR′, N(R′)C(O)R′, N(R′)N(R′), N(R′)C(S)R′, N(R′)C(O)N(R′) 2 , N(R′)C(S)N(R′) 2 , N(COR′)COR′, N(OR′)R′, C(═NH)N(R′) 2 , C(O)N(OR′)R′, or C(═NOR′)R′; and
R′ is independently at each occurrence hydrogen or alkyl, and
wherein the compound is not 4-[5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-dihydroinden-1-one.

2. A compound having the following structure:

or pharmaceutically acceptable salt thereof.

Assignees

• Scripps Research Inst

Inventors

• Roberts Edward
• Rosen Hugh
• Brown Steven
• Guerrero Miguel A
• Peng Xuemei
• Poddutoori Ramulu

Classifications

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title

• C07D413/04 Primary

  directly linked by a ring-member-to-ring-member bond · CPC title

• C07D413/14

  containing three or more hetero rings · CPC title