Amino acid derivatives and their uses

Patent metadata

Field	Value
Publication number	US-9975847-B2
Application number	US-201514938334-A
Country	US
Kind code	B2
Filing date	Nov 11, 2015
Priority date	Nov 11, 2014
Publication date	May 22, 2018
Grant date	May 22, 2018

Abstract

Provided are compounds described by the Formula I:

wherein: R 1 is a linear or branched, saturated or unsaturated aliphatic group having from 5 to 22 carbon atoms; R 2 is selected from the group consisting of the functional groups:

and salts thereof; n is from 0 to 4; and R 3 is a linear or branched, saturated or unsaturated aliphatic group having from 1 to 6 carbon atoms. Also provided are compositions comprising, and methods of use of, the compounds of the present invention.

First claim

What is claimed is:

1. A compound selected from the group consisting of:

and salts thereof, said salts having an anion X − preferably selected from the group consisting of acetate, benzoate, besylate, bromide, chloride, chlortheophyllinate, citrate, ethandisulfonate, fumarate, gluconate, hippurate, iodide, fluoride, lactate, laurylsulfate, malate, laeate, mesylate, methysulfate, napsylate, nitrate, octadecanoate, oxalate, pamoate, phosphate, polygalacturonate, succinate, sulfate, tartrate, and tosylate.

2. The compound of claim 1 selected from the group consisting of:

and salts thereof, said salts having an anion X − preferably selected from the group consisting of acetate, benzoate, besylate, bromide, chloride, chlortheophyllinate, citrate, ethandisulfonate, fumarate, gluconate, hippurate, iodide, fluoride, lactate, laurylsulfate, malate, laeate, mesylate, methysulfate, napsylate, nitrate, octadecanoate, oxalate, pamoate, phosphate, polygalacturonate, succinate, sulfate, tartrate, and tosylate.

3. The compound of claim 1 selected from the group consisting of:

and salts thereof, said salts having an anion X − preferably selected from the group consisting of acetate, benzoate, besylate, bromide, chloride, chlortheophyllinate, citrate, ethandisulfonate, fumarate, gluconate, hippurate, iodide, fluoride, lactate, laurylsulfate, malate, laeate, mesylate, methysulfate, napsylate, nitrate, octadecanoate, oxalate, pamoate, phosphate, polygalacturonate succinate, sulfate, tartrate, and tosylate.

4. The compound of claim 2 selected from the group consisting of:

5. The compound of claim 1 wherein said compound is

6. The compound of claim 1 wherein said compound is

7. The compound of claim 1 wherein said compound is

8. The compound of claim 1 wherein said compound is

9. The compound of claim 1 wherein said compound is

10. The compound of claim 1 wherein said compound is

11. The compound of claim 1 wherein said compound is

12. A composition comprising a compound of claim 1 and a vehicle wherein said composition is in a form selected form the group consisting of a mouthwash, mouth rinse, mouth spray, toothpaste, tooth gel, sub-gingival gel, mousse, foam, denture care product, dentifrice, lozenge, and chewable tablet.

13. The composition of claim 12 wherein said composition is a mouthwash comprising a carrier comprising water; and at least one surfactant selected from the group consisting of anionic, non-ionic, betaine surfactants and combinations of two or more thereof.

14. The composition of claim 13 further comprising at least one essential oil selected from the group consisting of menthol, thymol, eucalyptol, methyl salicylate, and combinations of two or more thereof.

15. The composition of claim 14 wherein said compound of claim 1 is

16. The composition of claim 14 wherein said compound of claim 1 is

17. The composition of claim 14 wherein said compound of claim 1 is

18. The composition of claim 14 wherein said compound of claim 1 is

19. The composition of claim 14 wherein said compound of claim 1 is

20. A method of inhibiting plaque in the oral cavity comprising contacting a surface of the oral cavity with a compound of claim 1 .

Assignees

• Johnson & Johnson Consumer Inc

Inventors

• Gambogi Robert J
• Geonnotti Iii Anthony R
• Giano Michael C
• Petersen Latrisha

Classifications

• C07C237/22

  having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated (peptides C07K) · CPC title

• A61K8/44

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title

• C07C279/12 Primary

  being further substituted by nitrogen atoms not being part of nitro or nitroso groups · CPC title

• A61K8/43 Primary

  Guanidines · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title