Process to produce an aqueous dispersion, an aqueous dispersion produced thereby and a coating composition comprising the aqueous dispersion

Patent metadata

Field	Value
Publication number	US-9969897-B2
Application number	US-201414914366-A
Country	US
Kind code	B2
Filing date	Aug 25, 2014
Priority date	Aug 29, 2013
Publication date	May 15, 2018
Grant date	May 15, 2018

Abstract

A process to produce a dispersion comprising feeding ethylcellulose polymer and a dispersant into a melt and mix zone of an extruder wherein the ethylcellulose polymer and dispersant are melted and mixed together to form a melt; conveying the melt to an emulsification zone of the extruder in which the temperature and pressure are controlled; feeding a base and water into the emulsification zone wherein the melt is dispersed to form a high internal phase emulsion; conveying the emulsion to a dilution and cooling zone of the extruder; and feeding water into the dilution and cooling zone to dilute the high internal phase emulsion thereby forming an aqueous dispersion is provided.

First claim

We claim:

1. A process to produce a dispersion comprising:
feeding ethylcellulose polymer into a melt and mix zone of an extruder via a feed throat,
feeding a liquid dispersant selected from saturated and unsaturated fatty acids into the melt and mix zone of the an extruder via a pump, wherein
the ethylcellulose polymer and dispersant are melted and mixed together to form a melt;
conveying the melt to an emulsification zone of the extruder in which the temperature and pressure are controlled;
feeding a base and water into the emulsification zone wherein the melt is dispersed to form a high internal phase emulsion;
conveying the emulsion to a dilution and cooling zone of the extruder; and
feeding water into the dilution and cooling zone to dilute the high internal phase emulsion thereby forming an aqueous dispersion.

2. The process according to claim 1 , comprising feeding ethylcellulose polymer and the dispersant in the absence of a plasticizer into the melt and mix zone of the extruder.

3. The process according to claim 1 , further comprising:
adding a plasticizer into the melt and mix zone of the extruder.

4. The process according to claim 1 , further comprising:
adding a plasticizer to the aqueous dispersion.

5. The process according to claim 3 , wherein the plasticizer is selected from the group consisting of esters of carboxylic acids.

6. The process according to claim 1 , wherein the ethylcellulose has a viscosity between 2 and 120 cP.

7. The aqueous dispersion produced by the process of claim 1 .

8. The aqueous dispersion according to claim 7 , wherein the aqueous dispersion has a pH equal to or less than 12.

9. The aqueous dispersion according to claim 7 , wherein the aqueous dispersion has a pH 8.0 to 9.5.

10. The aqueous dispersion according to claim 7 , wherein the aqueous dispersion has an volume average particle size less than or equal to 1.1 micron.

11. The aqueous dispersion according to claim 7 , wherein the aqueous dispersion has a solids content of equal to or less than 35 wt %.

12. The aqueous dispersion according to claim 7 , wherein the aqueous dispersion comprises 25 wt % solids, has a pH from 10.4 to 10.8 and a viscosity at 1 sec −1 of equal to or less than 100 cp at 25° C.

13. The aqueous dispersion according to claim 7 , wherein the aqueous dispersion comprises 25 wt % solids, has a pH from 8.5 to 9 and a viscosity at 1 sec −1 of equal to or less than 20 cp at 25° C.

14. The aqueous dispersion according to claim 7 , wherein the aqueous dispersion at pH of 10.6 exhibits a single diffusion coefficient, D, between 3×10 −11 and 6×10 −11 m 2 /s.

15. A pharmaceutical coating composition comprising at least one aqueous dispersion according to claim 7 .

16. A food coating composition comprising at least one aqueous dispersion according to claim 7 .

Assignees

• Dow Global Technologies Llc
• Union Carbide Chem Plastic
• Rohm & Haas

Inventors

• Rogers True L
• Izmitli Aslin
• Jordan Susan L
• Malotky David L
• Workentine Shari L
• Beshah Kebede

Classifications

• A61K9/10

  Dispersions; Emulsions · CPC title

• C08J3/03 Primary

  in aqueous media · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61K31/4402

  only substituted in position 2, e.g. pheniramine, bisacodyl · CPC title

• A23P20/105

  Coating with compositions containing vegetable or microbial fermentation gums, e.g. cellulose or derivatives; Coating with edible polymers, e.g. polyvinyalcohol · CPC title