Inhibitors of HIF prolyl hydroxylase

Patent metadata

Field	Value
Publication number	US-9969752-B2
Application number	US-201515514536-A
Country	US
Kind code	B2
Filing date	Sep 23, 2015
Priority date	Sep 28, 2014
Publication date	May 15, 2018
Grant date	May 15, 2018

Abstract

The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

First claim

What is claimed is:

1. A compound of formula I or a pharmaceutically acceptable salt thereof:

wherein:
Y is CH or N;
X is O, CH 2 , S, S(O), S(O) 2 , NH or N-Me;
m is 0, 1, 2 or 3;
n is 0, 1 or 2;
p is 0 or 1;
R 1 is independently selected from aryl, heterocyclyl, -Me-aryl, and -Me-heterocyclyl, said aryl and heterocyclyl are optionally substituted with 1, 2, or 3 substituents independently selected from: halogen, CF 3 , phenyl, CN, S(O) 2 R b , and heterocyclyl, wherein said phenyl and heterocyclyl are optionally substituted with 1, 2, or 3 substituents independently selected from:
CF 3 , halogen, C(O)N(R b ) 2 , N(R b ) 2 , C 1-4 alkyl, O(C 1-4 )alkyl, and CN;
R 2 is hydrogen or methyl;
R 3 and R 4 are each independently selected from hydrogen, hydroxyl, and C 1-4 alkyl, said alkyl optionally substituted with OH;
R 5 is independently selected from OH, halogen, CF 3 , OCF 3 , CN, C 1-4 alkyl, O(C 1-4 )alkyl, S(O) 2 R b , C 3-6 cycloalkyl, phenyl, and heterocyclyl, said cycloalkyl and heterocyclyl are optionally substituted with 1, 2, or 3 substituents independently selected from: OH, C 1-4 alkyl, O(C 1-4 )alkyl, S(O) 2 R b , C(O)N(R b ) 2 , and N(R b ) 2 ; and
R b is independently hydrogen or C 1-4 alkyl.

2. A compound according to claim 1 of formula II or a pharmaceutically acceptable salt thereof:

wherein:
Y is CH or N;
X is O, CH 2 , S, S(O), S(O) 2 , NH or N-Me;
m is 0, 1 or 2;
n is 0 or 1;
p is 0 or 1;
R 1 is independently selected from phenyl, -Me-phenyl, thiazolyl, -Me-thiazolyl, pyridinyl and oxazolyl, all of which are optionally substituted with 1 or 2 substituents independently selected from: Br,F, Cl, CF 3 , phenyl, CN, S(O) 2 R b , pyrazolyl, and pyridinyl, wherein said phenyl, pyrazolyl and pyridinyl are optionally substituted with 1 or 2 substituents independently selected from: CF 3 , Cl, C(O)N(R b ) 2 , N(R b ) 2 , C 1-4 alkyl, O(C 1-4 )alkyl, and CN;
R 5 is independently selected from OH, Br, F, Cl, CF 3 , OCF 3 , CN, C 1-4 alkyl, O(C 1-4 )alkyl, S(O) 2 R b , cyclopropyl, phenyl, isoxazolyl, pyrazolyl, pyrimidinyl and pyridinyl, said cyclopropy, phenyl, isoxazolyl, pyrazolyl, pyrimidinyl and pyridinyl are optionally substituted with 1 or 2 substituents independently selected from: OH, C 1-4 alkyl, O(C 1-4 )alkyl, S(O) 2 R b , C(O)N(R b ) 2 , and N(R b ) 2 ; and
R b is independently hydrogen or C 1-4 alkyl.

3. A compound which is:
2-(7-Hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-5-oxo-3-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(9-Cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(9-Bromo-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-9-(methylsulfonyl)-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H -[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-hydroxy-9-methyl-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(9-(1,2-Dihydroxypropan-2-yl)-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(1-Hydroxy-3-oxo-6-(4-(trifluoromethyl)phenyl)-3,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxamido)acetic acid;
2-(7-Hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(8-Bromo-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-8-(methylsulfonyl)-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(8-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(9-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(9-Bromo-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-9-(methylsulfonyl)-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-9-methyl-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(10-Cyano-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(10-Bromo-7-hydroxy-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-10-(methylsulfonyl)-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-10-methyl-5-oxo-2-(4-(trifluoromethyl)phenyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(8-bromo-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(10-Bromo-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-8-(methylsulfonyl)-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(8-Cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-8-methyl-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-10-(methylsulfonyl)-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(10-Cyano-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-10-methyl-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(9-acetyl-7-hydroxy-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-9-(1-hydroxyethyl)-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-9-(2-hydroxypropan-2-yl)-5-oxo-3-(4-(trifluoromethyl)benzyl)-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(10-cyano-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-10-(methylsulfonyl)-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-Hydroxy-10-methyl-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-hydroxy-5-oxo-10-phenyl-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(9-Cyano-7-hydroxy-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-hydroxy-9-(methylsulfonyl)-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(7-hydroxy-9-methyl-5-oxo-3,5-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamido)acetic acid;
2-(8-Cyano-1-hydroxy-3-

Assignees

• Merck Sharp & Dohme
• Msd R&D China Co Ltd

Inventors

• Cai Jiaqiang
• Crespo Alejandro
• Du Xiaoxing
• Dubois Byron Gabriel
• Guiadeen Deodialsingh
• Kothandaraman Shankaran
• Liu Ping
• Liu Rongqiang
• Quan Weiguo
• Sinz Christopher
• Wang Liping

Classifications

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P7/06

  Antianaemics · CPC title

• C07D498/16

  Peri-condensed systems · CPC title

• C07D471/06

  Peri-condensed systems · CPC title

• C07D498/06

  Peri-condensed systems · CPC title