N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors

US9969694B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9969694-B2
Application numberUS-201314442576-A
CountryUS
Kind codeB2
Filing dateNov 12, 2013
Priority dateNov 13, 2012
Publication dateMay 15, 2018
Grant dateMay 15, 2018

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Abstract

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Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

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Classifications

  • Antineoplastic agents · CPC title

  • containing three or more hetero rings · CPC title

  • linked by a chain containing hetero atoms as chain links · CPC title

  • Ortho-condensed systems · CPC title

  • containing three or more hetero rings · CPC title

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What does patent US9969694B2 cover?
Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseas…
Who is the assignee on this patent?
Array Biopharma Inc
What technology area does this patent fall under?
Primary CPC classification C07D231/52. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue May 15 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).