Low water stannous fluoride plus zinc citrate dentifrice with improved stability, rheology, and efficacy

Patent metadata

Field	Value
Publication number	US-9968803-B2
Application number	US-200913503801-A
Country	US
Kind code	B2
Filing date	Oct 29, 2009
Priority date	Oct 29, 2009
Publication date	May 15, 2018
Grant date	May 15, 2018

Abstract

A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.

First claim

We claim:

1. A dentifrice composition comprising in a single phase:
an orally acceptable vehicle;
a source of fluoride ions;
a source of stannous ions;
a source of zinc ions; and
at least one polyphosphate salt selected from the group consisting of inorganic polyphosphate salts which have equal to or less than three phosphorous atoms;
wherein
the dentifrice composition has a total water content of less than about 10% based on the weight of the composition; and
the vehicle comprises a thickening agent comprising, in combination, a cross-linked polyvinylpyrrolidone present in an amount of 0.75 to 1.25 wt % of the composition and xanthan gum present in an amount from about 0.2 to 0.3 wt % of the composition.

2. The composition of claim 1 , wherein the at least one polyphosphate is selected from the group consisting of an alkali metal salt of a pyrophosphate, an alkali metal salt of a tripolyphosphate, and mixtures thereof.

3. The composition of claim 2 , wherein the at least one polyphosphate is selected from the group consisting of tetrasodium pyrophosphate, sodium tripolyphosphate, and mixtures thereof.

4. The composition of claim 3 , wherein the at least one polyphosphate comprises a mixture of tetrasodium pyrophosphate and sodium tripolyphosphate.

5. The composition of claim 4 , wherein the mixture of tetrasodium pyrophosphate and sodium tripolyphosphate comprises tetrasodium pyrophosphate and sodium tripolyphosphate in about a 2:3 weight ratio.

6. The composition of claim 1 , wherein the at least one polyphosphate comprises from 1 to 10 wt % of the composition.

7. The composition of claim 6 , wherein the at least one polyphosphate comprises from 3 to 7 wt % of the composition.

8. The composition of claim 1 , wherein the source of fluoride ions and the source of stannous ions comprises stannous fluoride.

9. The composition of claim 1 , wherein the source of zinc ions comprises a zinc salt of an organic acid.

10. The composition of claim 9 , wherein the source of zinc ions comprises zinc citrate.

11. The composition of claim 1 , further comprising an aqueous buffer system for the source of stannous ions.

12. The composition of claim 11 , wherein the buffer system is adapted to chelate the stannous ions in the composition.

13. The composition of claim 12 , wherein the buffer system comprises at least one of an organic acid or an alkali metal salt thereof.

14. The composition of claim 13 , wherein the organic acid is citric acid.

15. The composition of claim 13 , wherein the buffer system comprises a mixture of citric acid and trisodium citrate.

16. The composition of claim 13 , wherein the buffer system comprises from 0.1 to 10 wt % of the composition.

17. The composition of claim 13 , wherein the buffer system is present, by weight, in an amount which is greater than the amount, by weight, of the source of stannous ions.

18. A method for the treatment and prevention of bacterial plaque accumulation or prevention of tooth erosion, comprising administering to the oral cavity the dentifrice composition according to claim 1 .

Assignees

• Fruge Linh
• Fisher Steven Wade
• Prencipe Michael
• Colgate Palmolive Co

Inventors

• Fruge Linh
• Fisher Steven Wade
• Prencipe Michael

Classifications

• A61P31/04

  Antibacterial agents · CPC title

• A61K8/24

  Phosphorous; Compounds thereof · CPC title

• A61K8/365

  Hydroxycarboxylic acids; Ketocarboxylic acids · CPC title

• A61K2800/31

  Anhydrous · CPC title

• A61K8/20 Primary

  Halogens; Compounds thereof · CPC title