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Stimuli responsive compositions for iron chelation
US9968633B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9968633-B2 |
| Application number | US-201514876740-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 6, 2015 |
| Priority date | Oct 7, 2014 |
| Publication date | May 15, 2018 |
| Grant date | May 15, 2018 |
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Abstract
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The present technology provides new compositions comprising at least one cross-linked co-polymer. In some embodiments, the polyacrylamide co-polymer comprises water soluble subunits, cross-linking subunits, and iron chelating subunits. In other embodiments, the co-polymer comprises water soluble units, cross-linking subunits, and substituted subunits, which can be conjugated with iron-chelating agents. When these new particles are exposed to certain environments, such the presence of strong acids or oxidation agents, these particles are capable of breaking up so that the iron chelating agents can chelate iron or other metals from their environments. Methods to prepare these new compositions are also provided. These compositions or compositions comprising nanogels of the present technology may be used to treat metal overload conditions such as iron overload resulting from chronic transfusions.
First claim
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We claim: 1. A composition comprising at least one cross-linked polyacrylyl co-polymer, wherein: the cross-linked polyacrylyl co-polymer comprises water soluble acrylyl subunits, stimuli-responsive cross-linking subunits, and iron-chelating subunits, wherein each subunit is attached to at least one or two other subunits at the former vinyl carbons; wherein the composition is a nanogel, and the water soluble acrylyl subunits are derived from acrylamido and/or acrylic monomers…
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Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US9968633B2 cover?
- The present technology provides new compositions comprising at least one cross-linked co-polymer. In some embodiments, the polyacrylamide co-polymer comprises water soluble subunits, cross-linking subunits, and iron chelating subunits. In other embodiments, the co-polymer comprises water soluble units, cross-linking subunits, and substituted subunits, which can be conjugated with iron-chelating…
- Who is the assignee on this patent?
- Xiong May Pang, Liu Zhi, Wang Yan, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/785. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 15 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).