Magnetically controlled permeability membranes

Patent metadata

Field	Value
Publication number	US-9968549-B2
Application number	US-201313800564-A
Country	US
Kind code	B2
Filing date	Mar 13, 2013
Priority date	Mar 23, 2012
Publication date	May 15, 2018
Grant date	May 15, 2018

Abstract

A bioactive material delivery system can include a thermoresponsive polymer membrane and nanowires distributed within the thermoresponsive polymer membrane. Magnetic activation of a thermoresponsive polymer membrane can take place via altering the magnetization or dimensions of nanowires dispersed or ordered within the membrane matrix.

First claim

What is claimed is:

1. A delivery device comprising:
a reservoir that contains a bioactive material to be delivered to a patient;
a thermoresponsive polymer membrane covering the reservoir; and
a plurality of magnetic nanowires distributed within the thermoresponsive polymer membrane,
wherein the plurality of magnetic nanowires responds to a magnetic field whereby a permeability of the thermoresponsive polymer membrane is altered in a presence of the magnetic field such that the bioactive material is released from the reservoir by passing through the plurality of magnetic nanowires and the thermoresponsive polymer membrane in an altered condition and not in an unaltered condition.

2. The device of claim 1 , wherein the thermoresponsive polymer membrane is-made of poly(N-isopropylacrylamide) (PNIPAAm), poly(D,L-lactic-co-glycolic acid) or any combination thereof.

3. The device of claim 1 , wherein the reservoir is configured to contain the bioactive material in contact with the thermoresponsive polymer membrane.

4. The device of claim 1 , wherein the reservoir is configured to contain the bioactive material.

5. The device of claim 1 , wherein the plurality of nanowires are oriented within the thermoresponsive polymer membrane.

6. The device of claim 1 , wherein the plurality of nanowires are randomly distributed within the thermoresponsive polymer membrane.

7. The device of claim 1 , wherein the plurality of nanowires form a pattern within the thermoresponsive polymer membrane.

8. The device of claim 7 , wherein the pattern includes a first region having a first density of nanowires and a second region having a second density of nanowires, the first density of nanowires being higher than the second density of nanowires.

9. The device of claim 1 , wherein at least a portion of the plurality of nanowires are magnetic.

10. The device of claim 1 , wherein the plurality of nanowires have a patterned distribution within the thermoresponsive polymer membrane.

Assignees

• Univ King Abdullah Sci & Tech

Inventors

• Kosel Jürgen
• Khashab Niveen
• Zaher Amir

Classifications

• A61M37/00

  Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title

• A61K9/0009 Primary

  involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis · CPC title

• A61K9/0024

  Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L) · CPC title