Phenylacetylenes

Patent metadata

Field	Value
Publication number	US-9964531-B2
Application number	US-201414760696-A
Country	US
Kind code	B2
Filing date	Jan 21, 2014
Priority date	Jan 23, 2013
Publication date	May 8, 2018
Grant date	May 8, 2018

Abstract

Disclosed herein are host or receptor compounds that bind targets of interest. In one embodiment the compounds bind ions, such as metal ions.
A compound, or a protonate or salt thereof, having the formula of:

Formula IIa
wherein R 6 is an aminoalkoxy, alkylamino, nitro or —NH 2 ;
n is 1 or 2;
each R 2 is independently selected from an optionally substituted alkyl, halogen, optionally substituted alkoxy, optionally substituted carboxyl, or amide;
a is 0 to 4.

First claim

What is claimed is:

1. A compound, or a protonate or salt thereof, having the formula of:

wherein R 6 is an aminoalkoxy, alkylamino, nitro or —NH 2 ;
each R 2 is independently selected from an optionally substituted alkyl, halogen, optionally substituted alkoxy, optionally substituted carboxyl, or amide; and
a is 0 to 4.

2. The compound of claim 1 , wherein R 6 is —O(CH 2 ) d NR 11 R 12 , wherein d is 1 to 10; and each R 11 and R 12 is independently H or lower alkyl.

3. The compound of claim 2 , wherein each of R 11 and R 12 is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, or tert-butyl.

4. The compound of claim 2 , wherein each of R 11 and R 12 is H.

5. The compound of claim 2 , wherein each of R 11 and R 12 is methyl.

6. The compound of claim 2 , wherein d is 2.

7. The compound of claim 1 , wherein a is 0.

8. The compound of claim 1 , wherein R 2 is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, or tert-butyl.

Assignees

• Univ Oregon

Inventors

• Haley Michael M
• Johnson Darren W
• Engle Jeff
• Carroll Calden

Classifications

• Y10T436/193333

  In aqueous solution · CPC title

• G01N31/22

  using chemical indicators (G01N31/02 takes precedence) · CPC title

• C07D213/68

  attached in position 4 · CPC title

• C07D213/56

  Amides · CPC title

• C07D207/335

  Radicals substituted by nitrogen atoms not forming part of a nitro radical · CPC title