Anti-human folate receptor beta antibodies and methods of use

Patent metadata

Field	Value
Publication number	US-9963505-B2
Application number	US-201615094211-A
Country	US
Kind code	B2
Filing date	Apr 8, 2016
Priority date	Sep 9, 2010
Publication date	May 8, 2018
Grant date	May 8, 2018

Abstract

Human anti-human folate receptor beta antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory disorders or cancers expressing cell surface FRβ.

First claim

What is claimed is:

1. A method of treating a patient having an inflammatory disorder, said method comprising administering to said patient an amount of an isolated human monoclonal antibody, or an antigen-binding fragment thereof, that specifically binds human folate receptor beta (FRβ) effective to reduce the number of FRβ positive macrophages and FRβ positive monocytes in said patient, wherein the antibody or fragment comprises
a heavy chain variable region (V H ) complementarity determining region (CDR) 1 comprising the amino acid sequence set forth in SEQ ID NO:1;
a V H CDR2 comprising the amino acid sequence set forth in SEQ ID NO:2;
a V H CDR3 comprising the amino acid sequence set forth in SEQ ID NO:3;
a light chain variable region (V L ) CDR1 comprising the amino acid sequence set forth in SEQ ID NO:4;
a V L CDR2 comprising the amino acid sequence set forth in SEQ ID NO:5; and
a V L CDR3 comprising the amino acid sequence set forth in SEQ ID NO:6; or
wherein the antibody or fragment comprises
a V H CDR1 comprising the amino acid sequence set forth in SEQ ID NO:1;
a V H CDR2 comprising the amino acid sequence set forth in SEQ ID NO:2;
a V H CDR3 comprising the amino acid sequence set forth in SEQ ID NO:3;
a V L CDR1 comprising the amino acid sequence set forth in SEQ ID NO:14;
a V L CDR2 comprising the amino acid sequence set forth in SEQ ID NO:15; and
a V L CDR3 comprising the amino acid sequence set forth in SEQ ID NO:16.

Assignees

• Purdue Research Foundation
• Us Health

Inventors

• Low Philip S
• Dimitrov Dimiter S
• Feng Yang
• Shen Jiayin

Classifications

• A61P35/00

  Antineoplastic agents · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• C07K2317/92

  Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value · CPC title

• C07K2317/33

  Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity · CPC title

• C07K2317/21

  from primates, e.g. man · CPC title