Method for the production of vitamin E with a high purity, vitamin E produced by said method, and a composition comprising said vitamin E

Patent metadata

Field	Value
Publication number	US-9963438-B2
Application number	US-201615258111-A
Country	US
Kind code	B2
Filing date	Sep 7, 2016
Priority date	May 18, 2015
Publication date	May 8, 2018
Grant date	May 8, 2018

Abstract

A method is provided for manufacturing high-purity vitamin E compounds by selectively separating vitamin E compounds such as tocotrienols and tocopherols from oil raw materials such as deodorized distillate, and more specifically, a method is provided, applying to a rich fraction of vitamin E compounds, for obtaining high-purity vitamin E compounds by separating and removing only free fatty acids contained as impurities. The method comprises a process in which a solution containing vitamin E compounds and free fatty acids is placed in contact with a weakly basic anion exchanger, and the free fatty acids are preferentially adsorbed.

First claim

The invention claimed is:

1. A method of manufacturing a high-purity vitamin E compound comprising contacting a solution comprising a vitamin E compound and a free fatty acid with a weakly basic anion exchanger having a functional group pKa of 7-9, wherein the free fatty acid is adsorbed.

2. The method of claim 1 , wherein the weakly basic anion exchanger is a weakly basic anion exchange resin.

3. The method of claim 1 , wherein the free fatty acid is at least one organic acid having a carbon number of 1-30.

4. The method of claim 1 , wherein the vitamin E compound is contained in at least one oil selected from the group consisting of deodorizer distillate (scum oil), fatty acid oil, dark oil, crude oil, and edible oil.

5. The method of claim 1 , further comprising obtaining a rich fraction of vitamin E compound by adsorbing the vitamin E compound contained in an oil to a strongly basic ion exchanger and then desorbing the vitamin E compound from the strongly basic anion exchanger to obtain the rich fraction of vitamin E compound.

6. The method of claim 5 , further comprising esterification of free fatty acid contained in the oil by using a strongly acidic cation exchanger before the adsorbing and desorbing of the vitamin E compounds contained in the oil, to and from the strongly basic anion exchanger.

7. The method of claim 1 , further comprising a continuous reaction using reactors filled with a strongly acidic cation exchanger, strongly basic anion exchanger, and/or a weakly basic anion exchange resin.

8. A method of separating and removing a free fatty acid contained as an impurity in a vitamin E compound, the method comprising:
contacting an oil comprising a vitamin E compound with a weakly basic anion exchanger having a functional group pKa of 7-9, and
adsorbing a free fatty acid to the weakly basic anion exchanger.

Assignees

• Univ Tohoku

Inventors

• SHIBASAKI-KITAKAWA Naomi
• Hiromori Kousuke
• Kanuma Kousei
• SASAYAMA Tomone

Classifications

• C07D311/72 Primary

  3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols · CPC title

• B01D15/362

  Cation-exchange · CPC title

• B01D15/363

  Anion-exchange · CPC title

• B01J41/07

  in the weakly basic form · CPC title

• B01J39/05

  in the strongly acidic form · CPC title