Analyzing device

Patent metadata

Field	Value
Publication number	US-9962700-B2
Application number	US-201514692315-A
Country	US
Kind code	B2
Filing date	Apr 21, 2015
Priority date	Jul 17, 2008
Publication date	May 8, 2018
Grant date	May 8, 2018

Abstract

An analyzing device includes: an operation cavity that is adjacent to a first reserving cavity retaining a sample liquid, in a circumferential direction of rotational driving; a connecting section provided on a side wall of the first reserving cavity to suck the sample liquid by a capillary force and transfer the sample liquid to the operation cavity; and second reserving cavities that are disposed outside the operation cavity in the circumferential direction of the rotational driving and communicate with the outermost position of the operation cavity through a connecting passage. The connecting section is circumferentially extended farther than the liquid level of the sample liquid retained in the first reserving cavity.

First claim

The invention claimed is:

1. An analyzing device having a microchannel structure for transferring a sample liquid, comprising:
a rotation center around which the analyzing device is rotated;
an outer periphery defining an outer contour of the analyzing device;
a reserving cavity that measures a fixed quantity of a diluent, the reserving cavity being located at a distance from the rotation center;
a mixing cavity located farther from the rotation center than the reserving cavity and connected to the reserving cavity via a connecting passage to receive the diluent from the reserving cavity and mix the sample liquid with the diluent;
an overflow cavity located farther away from the rotation center than the reserving cavity and connected to the reserving cavity, wherein an excess quantity of the diluent flows from the reserving cavity into the overflow cavity;
a chamber located farther from the rotation center than the overflow cavity, and connected to the reserving cavity via the overflow cavity, wherein the excess quantity of the diluent is transferred from the reserving cavity to the chamber via the overflow cavity when a centrifugal force is generated by a rotation of the analyzing device around the rotation center;
a measurement spot located in a different circumferential location from the mixing cavity;
a capillary passage that connects the mixing cavity to the measurement spot in a circumferential direction and transfers the sample liquid from the mixing cavity to the measuring spot by a capillary force; and
a sealing overflow cavity between an atmospheric-side overflow cavity communicating with atmosphere and the chamber, the sealing overflow cavity communicating with the chamber via a first overflow passage and communicating with the atmospheric-side overflow cavity via a second overflow passage,
wherein the portion of the capillary passage crosses the overflow cavity so that the overflow cavity is divided into two parts, with one part of the overflow cavity being closer to the rotation center than another part of the overflow cavity, the overflow cavity allowing the excess diluent to flow from the reserving cavity into the chamber over the capillary passage by the centrifugal force,
wherein the measurement spot and the mixing cavity are located along the outer periphery at a generally common distance away from the rotation center, and
wherein outlets of the chamber and the sealing overflow cavity are sealed from the atmosphere and a negative pressure is generated in the chamber and the sealing overflow cavity when the sample liquid is transferred from the mixing cavity through the capillary passage.

2. The analyzing device according to claim 1 , wherein the measurement spot to which the sample liquid is transferred, is located closer to the rotation center than the mixing cavity.

3. The analyzing device according to claim 1 , further comprising a base substrate and a cover substrate and a thickness defined between the base and cover substrates, wherein the base substrate has a raised floor in the capillary passage compared to a floor of the overflow cavity such that a thickness of the capillary passage is smaller than a thickness of the overflow cavity.

4. The analyzing device according to claim 1 , wherein the reserving cavity is connected to the mixing cavity via a siphon-shaped connecting passage.

5. The analyzing device according to claim 1 , wherein the portion of the capillary passage that connects the mixing cavity to the measurement spot divides the overflow cavity into the two parts.

Assignees

• Panasonic Healthcare Co Ltd
• Panasonic Healthcare Holdings Co Ltd

Inventors

• Saiki Hiroshi

Classifications

• B01L2300/0803

  Disc shape · CPC title

• B01L2200/0652

  Sorting or classification of particles or molecules · CPC title

• B01L3/502753 Primary

  characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation · CPC title

• G01N35/00069

  whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk · CPC title

• B01L2200/0605

  Metering of fluids · CPC title