Adhesion-preventing preparation comprising composition comprising polycationic triblock copolymer and polyanionic polymer

Patent metadata

Field	Value
Publication number	US-9962469-B2
Application number	US-201515116577-A
Country	US
Kind code	B2
Filing date	Jan 27, 2015
Priority date	Feb 5, 2014
Publication date	May 8, 2018
Grant date	May 8, 2018

Abstract

[Problem] To provide a composition capable of effectively preventing adhesion.
[Solution] An adhesion-preventing preparation comprising, as an active ingredient, a composition comprising an A-B-A triblock copolymer, in which A denotes a cationically chargeable polymer block and B denotes a water-soluble block that comprises a poly(ethylene glycol) (or poly(oxyethylene)) chain, and a polyanionic polymer.

First claim

The invention claimed is:

1. A method for preventing adhesion of tissues or organs in a living body, comprising administering a composition comprising a triblock copolymer and a polyanionic polymer to a site in a living body that requires administration, at a quantity that is effective to prevent adhesion of tissues or organs of a patient, wherein
the triblock copolymer is represented by formula (II),

wherein:
L 1 ′ is each independently selected from the group consisting of

L 2 is each independently a —C 1-6 alkylene-NH—(C 1-6 alkylene) q - group, wherein q is an integer of 0 or 1,
R is each independently a group such that at least 20% of the total number (n) of R groups are residues of cyclic nitroxide radical compounds selected from the group consisting of 2,2,6,6-tetramethylpiperidin-1-oxyl-4-yl groups, 2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-yl groups, 2,2,5,5-tetramethylpyrrolin-1-oxyl-3-yl groups, 2,4,4-trimethyl-1,3-oxazolidin-3-oxyl-2-yl groups, 2,4,4-trimethyl-1,3-thiazolidin-3-oxyl-2-yl groups and 2,4,4-trimethyl-imidazolidin-3-oxyl-2-yl groups, wherein the remaining R groups, when present, are hydrogen atoms, halogen atoms or hydroxyl groups,
Y is each independently selected from the group consisting of hydrogen, a phenylthiocarbonylthio group optionally substituted by a C 1-6 alkyl group, a C 1-6 alkylthiocarbonylthio group and a C 1-6 alkyloxythiocarbonylthio group,
each m is independently an integer between 3 and 1000, and
n is an integer between 20 and 5000,

and
the anionic polymer is one or more types selected from the group consisting of a poly(acrylic acid), a poly(methacrylic acid), a poly(sulfonic acid), a polyanionic polysaccharide and an anionic protein.

Assignees

• Univ Tsukuba

Inventors

• Nagasaki Yukio
• Nakagawa Hiroyuki

Classifications

• A61K49/0004

  Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions · CPC title

• C08L33/02

  Homopolymers or copolymers of acids; Metal or ammonium salts thereof · CPC title

• A61P41/00

  Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution · CPC title

• A61L31/041 Primary

  Mixtures of macromolecular compounds · CPC title

• A61L31/145

  Hydrogels or hydrocolloids · CPC title