Techniques for manufacturing ingestible event markers comprising an ingestible component
US-2015164746-A1 · Jun 18, 2015 · US
US9962107B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9962107-B2 |
| Application number | US-201414308549-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 18, 2014 |
| Priority date | Apr 28, 2005 |
| Publication date | May 8, 2018 |
| Grant date | May 8, 2018 |
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The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.
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What is claimed is: 1. A method of manufacturing a plurality of communication devices, wherein each of the plurality of communication devices comprises a non-conducting membrane and a partial power source, the method comprising: cutting a plurality of openings into a sheet of non-conducting membrane material to produce an assembly membrane sheet, wherein the shape of each opening corresponds to the shape of a framework of each of the plurality of communication devices, and wherein each framework comprises a support structure comprising a plurality of surfaces; inserting one framework selected from a plurality of frameworks into each opening of the assembly membrane sheet, wherein each of the plurality of frameworks is prepared according to a process that comprises depositing a transition metal on an opposite surface of its respective support structure from a surface of its respective support structure having an adhesive material; depositing a conductive material onto the assembly membrane sheet on a side of the assembly membrane sheet opposite the transition metal to produce an adhesion membrane sheet, wherein the conductive material defines a plurality of holes; depositing a first material onto the adhesion membrane sheet on the side of the assembly membrane sheet with the adhesive material, wherein the first material adheres to the conductive material; and depositing a second material onto the transition metal to produce a partial power device sheet; wherein the partial power source of each of the plurality of communication devices comprises the first material and the second material which are configured to produce a voltage potential difference when the first material and the second material come into contact with an electrically conductive fluid. 2. The method of claim 1 , further comprising, defining a plurality of boundaries on each support structure of each framework, wherein each boundary corresponds to circuitry of each communication device. 3. The method of claim 2 , wherein depositing the conductive material further comprises defining a group of holes, wherein the group of holes is contained within one boundary selected from the plurality of boundaries such that the position of each hole within the group of holes is within the one boundary. 4. The method of claim 1 , further comprising depositing the first material over the adhesive material such that any edge of the first material is not positioned over any one of the plurality of holes. 5. The method of claim 4 , wherein an edge of the first material is positioned between any one edge of the adhesive material and a boundary containing the plurality of holes. 6. The method of claim 4 , wherein the plurality of holes is spaced a first distance from any one of the edges of the adhesive material. 7. The method of claim 6 , wherein the first distance is a minimum distance required to separate the plurality of holes from any one of the edges of the adhesive material to allow the plurality of holes to fall within a boundary such that any edge of the first material is not positioned over any one of the plurality of holes. 8. A method of manufacturing a plurality of communication devices, wherein each of the plurality of communication devices comprises a non-conducting membrane and a partial power source, the method comprising: cutting a plurality of openings into a sheet of non-conducting membrane material to produce an assembly membrane sheet, wherein the shape of each opening corresponds to the shape of a framework of each of the plurality of communication devices, and wherein each framework comprises a plurality of support surfaces; inserting one framework selected from a plurality of frameworks into each opening of the assembly membrane sheet, wherein each of the plurality of frameworks is prepared according to a process that comprises depositing a transition metal on an opposite support surface from a support surface having an adhesive material; depositing a conductive material onto the assembly membrane sheet on a side opposite the transition metal to produce an adhesion membrane sheet, wherein the conductive material defines a plurality of holes; depositing a first material onto the adhesion membrane sheet on the side with the adhesive material, wherein the first material adheres to the conductive material; depositing a second material onto the transition metal to produce a partial power device sheet, wherein the partial power source of each of the plurality of communication devices comprises the first material and the second material which are configured to produce a voltage potential difference when the first material and the second material come into contact with an electrically conductive fluid; and removing at least one of the plurality of communication devices from the assembly membrane sheet such that each removed communication device comprises a non-conducting membrane. 9. The method of claim 8 , wherein removing the at least one of the plurality of communication devices from the assembly membrane sheet comprises punching the at least one of the plurality of communication devices from the assembly membrane sheet with a punch press. 10. The method of claim 8 , further comprising applying a coating to the at least one of the plurality of communication devices after it is removed from the assembly membrane sheet. 11. The method of claim 1 , wherein depositing the first material comprises depositing a CuCl material. 12. The method of claim 1 , wherein depositing the second material comprises depositing a Mg material. 13. A method of manufacturing a plurality of communication devices, wherein each of the plurality of communication devices comprises a non-conducting membrane and a partial power source, the method comprising: cutting a plurality of openings into a sheet of non-conducting membrane material to produce an assembly membrane sheet, wherein the shape of each opening corresponds to the shape of a framework of each of the plurality of communication devices, and wherein each framework comprises a plurality of support surfaces; inserting one framework into each opening of the assembly membrane sheet, wherein each framework is prepared according to a process that comprises: depositing a transition metal on an opposite support surface from a support surface having an adhesive material; and heating the transition metal and its respective framework; depositing a conductive material onto a side of the assembly membrane sheet opposite the transition metal to produce an adhesion membrane sheet, wherein the conductive material defines a plurality of holes; depositing a first material onto the adhesion membrane sheet on the side with the adhesive material, wherein the first material adheres to the conductive material; and depositing a second material onto the transition metal to produce a partial power device sheet; wherein the partial power source of each of the plurality of communication devices comprises the first material and the second material which are configured to produce a voltage potential difference when the first material and the second material come into contact with an electrically conductive fluid. 14. The method of claim 13 , further comprising cleaning a surface of the transition metal after heating the transition metal and its respective framework. 15. The method of claim 14 , wherein cleaning the surface of the transition metal and heating the transition metal and its respective framework further comprises cleaning the surface of the transition metal and heating the transition metal and its respective framework ions using a
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