Chemical sensor, chemical sensor module, chemical substance detection apparatus, and chemical substance detection method

Patent metadata

Field	Value
Publication number	US-9958386-B2
Application number	US-201214358639-A
Country	US
Kind code	B2
Filing date	Nov 16, 2012
Priority date	Nov 30, 2011
Publication date	May 1, 2018
Grant date	May 1, 2018

Abstract

[Object] To provide a chemical sensor provided with a spectral filter excellent in spectral characteristic, a chemical sensor module, a chemical substance detection apparatus, and a chemical substance detection method.
[Solving Means] A chemical sensor according to the present technology is provided with a substrate and a plasmon absorption layer. On the substrate, the photodetection unit is formed. The plasmon absorption layer is laminated on the substrate and has a metal nanostructure that generates plasmon absorbency.

First claim

The invention claimed is:

1. A sensor, comprising:
a substrate;
at least one photodetection unit is diffused as impurity in the substrate; and
a plasmon absorption layer laminated on the substrate, wherein the plasmon absorption layer having a metal nanostructure that generates plasmon absorbency,
wherein the plasmon absorption layer contains a metal nanoparticle and the metal nanoparticle has a particle diameter of 1 nm or more and 150 nm or less.

2. The sensor according to claim 1 , further comprising
a surface layer laminated on the plasmon absorption layer, wherein the surface layer having a holding surface on which a detection target object is held.

3. The sensor according to claim 2 , wherein
the plasmon absorption layer blocks out illumination light with which the detection target object is irradiated, and
wherein the sensor further includes a fluorescent label that generates detection target light on the detection target object to pass therethrough.

4. The sensor according to claim 3 , wherein
the illumination light is excitation light, and
the detection target light is fluorescence.

5. The sensor according to claim 2 , wherein
the holding surface holds a probe material that is specifically bound to a target material to be detected.

6. The sensor according to claim 5 , wherein
the probe material is one of DNA, RNA, a protein, or an antigenic substance.

7. The sensor according to claim 1 , wherein
the metal nanoparticle is a particle having a surface of a metal that contains at least one of gold, silver, or copper and an alloy thereof.

8. The sensor according to claim 1 , further comprising
a color filter layer laminated between the substrate and the plasmon absorption layer, wherein a material of the color filter layer is an organic-dye based resin.

9. The sensor according to claim 1 , further comprising
a multilayer film filter layer that is based on an alternate lamination of a plurality of material that comprises TiO 2 and SiO 2 .

10. A sensor module, comprising:
a sensor including a substrate;
at least one photodetection unit that is diffused as impurity in the substrate;
a plasmon absorption layer laminated on the substrate, and a surface layer laminated on the plasmon absorption layer, wherein the plasmon absorption layer having a metal nanostructure that generates plasmon absorbency, wherein the plasmon absorption layer contains a metal nanoparticle and the metal nanoparticle has a particle diameter of 1 nm or more and 150 nm or less, and wherein the surface layer having a holding surface on which a detection target object is held; and
an illumination light source that irradiates the holding surface with illumination light.

11. A detection apparatus, comprising:
a sensor including a substrate;
at least one photodetection unit that is diffused as impurity in the substrate;
a plasmon absorption layer laminated on the substrate, and a surface layer laminated on the plasmon absorption layer, wherein the plasmon absorption layer having a metal nanostructure that generates plasmon absorbency, wherein the plasmon absorption layer contains a metal nanoparticle and the metal nanoparticle has a particle diameter of 1 nm or more and 150 nm or less, and wherein the surface layer having a holding surface on which a detection target object is held; and
a signal processing circuit that is connected to the sensor, wherein the signal processing circuit process an output signal of the at least one photodetection unit.

12. A detection method, comprising:
preparing a sensor including a substrate;
diffusing at least one photodetection unit as impurity in the substrate;
laminating, a plasmon absorption layer on the substrate, a surface layer on the plasmon absorption layer, wherein the plasmon absorption layer having a metal nanostructure that generates plasmon absorbency, wherein the plasmon absorption layer contains a metal nanoparticle and the metal nanoparticle has a particle diameter of 1 nm or more and 150 nm or less, and wherein the surface layer having a holding surface on which a detection target object is held;
causing a probe material to be held on the holding surface;
bringing a sample into contact with the holding surface and causing a target material contained in the sample to bind to the probe material to provide the detection target object, wherein a fluorescent label is introduced to at least one of a bound body of the probe material and the target material;
irradiating the holding surface with illumination light; and
detecting, by the at least one photodetection unit, detection target light generated based on the fluorescent label as a result of binding of the probe material and the target material on the detection target object upon receiving the illumination light.

13. The detection method according to claim 12 , wherein
the illumination light is excitation light, and
the detection target light is fluorescence.

14. The detection method according to claim 13 , further comprising
washing the holding surface before the fluorescent label is introduced to the at least one of a bound body of the probe material and the target material; and
detecting, by the at least one photodetection unit, changes in wavelength and luminance of the fluorescence caused by an interaction of the target material and the probe material fluorescently labeled in advance, to further detect the fluorescence.

15. The detection method according to claim 13 , further comprising
detecting, by the at least one photodetection unit, the fluorescence generated based on the target material that is labeled based on the fluorescent label, wherein the target material is bound to the probe material.

16. The detection method according to claim 13 , further comprising:
labelling of the fluorescent label for a bound body of the probe material and the target material, and
detecting the fluorescence by the at least one photodetection unit.

Assignees

• Sony Corp

Inventors

• Moriya Yusuke
• Matsuzawa Nobuyuki
• Maeda Kensaku

Classifications

• G01N21/553 Primary

  and using surface plasmons (fluorescence excitation G01N21/648; enhanced Raman G01N21/658) · CPC title

• G01J3/4406

  Fluorescence spectrometry · CPC title

• G01N2021/6471

  Special filters, filter wheel · CPC title

• G01N21/6454 Primary

  using an integrated detector array · CPC title