Fluidic device

Patent metadata

Field	Value
Publication number	US-9958369-B2
Application number	US-201314438145-A
Country	US
Kind code	B2
Filing date	Oct 22, 2013
Priority date	Oct 23, 2012
Publication date	May 1, 2018
Grant date	May 1, 2018

Abstract

A method for determining the diffusion of one or more components, the method includes the steps of (i) providing a component fluid flow having one or more components; (ii) providing a blank fluid flow; (iii) bringing the flow (i) into contact with the flow (ii) in a large cross section channel, thereby to generate two laminar flows; (iv) permitting the laminar flows generated in (iii) to flow from the large cross section channel into a small cross section channel; measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow in the small cross section channel. Also provided is a diffusion method having the steps of measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow at a plurality of diffusion times.

First claim

The invention claimed is:

1. A fluidic device for use in a method for determining the diffusion of one or more components, the device comprising a large cross section channel in fluid communication with two upstream supply channels, and a downstream small cross section channel in fluid communication with the large cross section channel such that laminar flows are permitted to flow from the large cross section channel into the small cross section channel; wherein the large and small cross section channels have dimensions that generate and maintain a laminar flow of two streams within the large and small cross section channels, when in use.

2. The fluidic device according to claim 1 , wherein the maximum width of the large cross section channel is at least 2 times the width of the small cross section channel.

3. The fluidic device according to claim 2 , wherein the maximum width of the large cross section channel is at least 10 times the width of the small cross section channel.

4. The fluidic device according to claim 1 , wherein the width of the small cross section is in the range 10 to 500 μm.

5. The fluidic device according to claim 1 , wherein the length of the large cross section channel is in the range 50 to 500 μm.

6. The fluidic device according to claim 1 , wherein the length of the small cross section channel is in the range 0.5 to 50 mm.

7. The fluidic device according to claim 1 , wherein the large cross section channel has a substantially constant maximum width region, which is upstream from a converging width region which converges from the substantially constant maximum width region to that of the small cross section channel.

8. The fluidic device according to claim 1 adapted for interaction with an analytical device for measuring diffusion in the small cross section channel.

9. The fluidic device according to claim 1 , wherein the large cross section channel has a maximum width region, which is upstream from a converging width region which converges from the maximum width region to that of the small cross section channel.

Assignees

• Cambridge Entpr Ltd

Inventors

• Cohen Samuel
• Knowles Tuomas
• Dobson Christopher
• Rajah Luke
• White Duncan

Classifications

• B01F5/045

  Operations & Transport · mapped topic

• B01F13/0093

  Operations & Transport · mapped topic

• G01N13/00 Primary

  Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects (scanning-probe techniques or apparatus G01Q) · CPC title

• G01N33/487

  of liquid biological material · CPC title

• B01F5/0647

  Operations & Transport · mapped topic