Methods for the treatment of diabetic retinopathy and other ophthalmic diseases

Patent metadata

Field	Value
Publication number	US-9957224-B2
Application number	US-201313887243-A
Country	US
Kind code	B2
Filing date	May 3, 2013
Priority date	May 4, 2012
Publication date	May 1, 2018
Grant date	May 1, 2018

Abstract

Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

First claim

What is claimed is:

1. A method for treating proliferative diabetic retinopathy in a patient having been previously diagnosed with proliferative diabetic retinopathy comprising administering to the patient a therapeutically effective amount of a composition comprising a compound, or stereoisomer, N-oxide or a pharmaceutically acceptable salt thereof, having the structure:

2. The method of claim 1 , wherein the composition is administered to the patient orally.

3. The method of claim 1 , wherein the composition is administered once per day, and the composition is administered in the evening or prior to going to sleep.

4. The method of claim 1 , wherein treatment results in improvement of central vision in the patient.

5. The method of claim 1 , 2 , 3 , or 4 , wherein the (R)-3-amino-1-(3-(cyclohexylmethoxy)phenyl)propan-1-ol is administered as a daily dose of about 2 mg; about 5 mg; about 7 mg; or about 10 mg.

Assignees

• Acucela Inc
• Acucela Inc

Inventors

• Bavik Claes Olof
• Henry Susan Hayes
• Kubota Ryo
• Kuksa Vladimir A

Classifications

• A61P39/00

  General protective or antinoxious agents · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P27/10

  for accommodation disorders, e.g. myopia · CPC title