Method for producing a fluidic connection component for chromatography

Patent metadata

Field	Value
Publication number	US-9956651-B2
Application number	US-201414200392-A
Country	US
Kind code	B2
Filing date	Mar 7, 2014
Priority date	Mar 12, 2013
Publication date	May 1, 2018
Grant date	May 1, 2018

Abstract

A method for producing a fluidic connection component for chromatography is described. A connection component includes a main body and at least one insert held in the main body. The main body is prefabricated with an aperture for the at least one insert. The at least one insert is connected to the main body securely and fluidically tightly by a thermal process and by making use of a thermal expansion of the main body and/or of the insert that occurs during the thermal process. The method may include a thermally induced change in volume of the main body and/or of the insert that is retained after completion of the thermal process. The material and the geometry of the main body and of the insert and the thermal process are chosen such that, after completion of the thermal treatment, there is a secure and fluidically tight connection.

First claim

What is claimed is:

1. A method for producing a fluidic connection component for chromatography, the fluidic component comprising a main body and at least one optical waveguide held in the main body, wherein the main body is prefabricated with at least one aperture for the at least one optical waveguide, the method comprising:
connecting the at least one optical waveguide to the main body securely and fluidically tightly by purely a thermal expansion of the main body or the optical waveguide, in which the thermal expansion only occurs during a thermal process, wherein there is no initial or full melting of a contact region between the main body and the at least one optical waveguide, and
after completion of the thermal process, retaining a thermally induced change in volume of the main body or of the optical waveguide to cause a radial clamping force between the main body and the optical waveguide to occur in a clamping region along a course of the aperture to form a secure and fluidically tight connection between the main body and the optical waveguide at temperatures within a working temperature range,
wherein a material with a first coefficient of thermal expansion is used for the main body and a material with a second coefficient of thermal expansion is used for the at least one optical waveguide, the first coefficient of thermal expansion is at least twice the second coefficient of thermal expansion, or a material with a third coefficient of thermal expansion is used for the at least one optical waveguide and a material with a fourth coefficient of thermal expansion is used for the main body, the third coefficient of thermal expansion is at least twice the fourth coefficient of thermal expansion.

2. The method of claim 1 , wherein the material with the first coefficient is a plastic and the material with the second coefficient is selected from the group consisting of a glass, a ceramic, a metal, and a metal alloy, or wherein the material with the third coefficient is selected from the group consisting of a glass, a ceramic, a metal, and a metal alloy and the material with the fourth coefficient is a plastic.

3. The method of claim 1 , wherein
a) an inner dimension of the aperture of the main body at a temperature within the working temperature range is smaller than a dimension of a cross section of the optical waveguide at a temperature within the working temperature range,
b) the method further comprising: adjusting a temperature of the main body and the optical waveguide to a predetermined common temperature outside of the working temperature range or a predetermined temperature difference between the material of the main body and the material of the optical waveguide,
c) inserting the optical waveguide into the aperture, and
d) securely holding the optical waveguide fluidically tightly in the main body when a temperature of the optical waveguide and the main body are within the working temperature range.

4. The method of claim 1 , wherein
a) the material used for the main body or for the at least one optical waveguide is
i) partially of a crystalline phase and partially of an amorphous phase,
ii) in which, when heated above a melting temperature for the crystalline phase, and the melting temperature is above the working temperature range, displays an increase in volume as a result of a conversion of part of the crystalline phase into the amorphous phase, and with a cooling does not have a complete restoration of the fraction of the crystalline phase that has been transformed into the amorphous phase back into the crystalline phrase, and
iii) in which, at a temperature within a conditioning range, in which the conditioning range is below the melting temperature of the crystalline phase and above the working temperature range, displays a decrease in volume as a result of a transformation of the amorphous of the amorphous phase into the crystalline phase, until a minimum volume is reached on reaching a maximum fraction of the crystalline phase, and

b) the method further comprising selecting a material and a fraction of the crystalline phase in the material of the prefabricated main body or the at least one optical waveguide and a temperature profile of the thermal process, where a secure fluidically tight connection between the at least one optical waveguide and the main body is obtained after the thermal process.

5. The method of claim 4 , wherein
a) an inner dimension of the aperture of the main body at a temperature within the working temperature range is greater than a dimension of a cross section of the optical waveguide at a temperature within the working temperature range,
b) the method further comprising: inserting the optical waveguide into the aperture,
c) heating the main body to a temperature within the conditioning range where the optical waveguide is held securely and fluidically tightly in the main body either at the temperature within the conditioning range or after cooling to a temperature within the working temperature range.

6. The method of claim 4 , wherein an expansion of an outer dimension of the main body during the thermal process on at least one outer surface of the main body is restricted by a molding element to cause a plastic deformation of the main body in a region of the at least one outer surface.

7. The method of claim 6 , wherein a structure of the outer surface is determined by the molding element.

8. The method of claim 6 , wherein the at least one outer surface is a closed annular surface.

9. The method of claim 6 , wherein an expansion of the outer dimension of the main body is in a region radially surrounding the clamping region and an additional increase in the radial clamping forces is produced in a region of the clamping region by the plastic deformation.

10. The method of claim 6 wherein, during the cooling or conditioning of the main body, a shrinkage process on at least one inner surface of the main body is restricted by the molding element to cause the plastic deformation of the main body to a defined form in a region of the at least one inner surface.

11. The method of claim 10 , wherein a structure of the inner surface of the main body is determined by the molding element.

12. The method of claim 11 , wherein the at least one inner surface is a closed annular surface.

13. The method of claim 1 , wherein the at least one optical waveguide has a coating, which is removed in a front region, in which the optical waveguide is connected to the main body by a thermal expansion and a shrinkage process.

14. The method of claim 13 , wherein a rearward partial region of the optical waveguide, in which the coating has been removed and which lies on a side of the clamping region that is facing away from the front end of the optical waveguide, is protected, and connected to the main body with an adhesive material.

15. The method of claim 1 , wherein the main body is prefabricated with at least two apertures, and the optical waveguide is inserted in one of said apertures and a fluid capillary is inserted in another of said apertures and are connected to the main body securely and fluidically tightly by a single thermal process.

16. The method of claim 1 further comprising: coupling the optical waveguide to a chromatography column.

17. The method of claim 1 further comprising: coupling the optical waveguide to a sensor.

18. A method for producing a fluidic connection component for chromatography, the fluidic connection component comprising a main body and a fluid capillary held in the main body, wherein the main

Assignees

• Dionex Softron Gmbh

Inventors

• Baigar Erik
• Hilmer Christian Andreas
• Unger Andreas

Classifications

• Y10T29/49863

  with prestressing of part · CPC title

• Y10T29/49865

  by temperature differential [e.g., shrink fit] · CPC title

• Y10T29/53704

  tool chuck and tool · CPC title

• B01L3/563

  Joints or fittings; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors · CPC title

• Y10T29/4987

  Elastic joining of parts · CPC title