Respiratory waveform analyzer

Patent metadata

Field	Value
Publication number	US-9955899-B2
Application number	US-74960710-A
Country	US
Kind code	B2
Filing date	Mar 30, 2010
Priority date	Mar 30, 2009
Publication date	May 1, 2018
Grant date	May 1, 2018

Abstract

A respiratory waveform analyzer, operable to analyze a respiratory waveform, which is generated based on a temporal change of a concentration of a component in respiratory gas of a subject, includes: a respiratory gas concentration generator which generates a concentration signal based on an output signal from a sensor that is placed to measure the concentration of the component; a flatness calculator which calculates a flatness indicative of flat degree of the respiratory waveform based on a temporal change of the concentration signal; and a reliability calculator which calculates a reliability of the respiratory waveform based on the flatness and the concentration signal.

First claim

What is claimed is:

1. An expiratory waveform analyzer, operable to analyze an expiratory waveform, which is generated based on a concentration of a component in expiratory gas of a subject measured over a plurality of time intervals, the expiratory waveform analyzer comprising:
an expiratory gas concentration generator which generates a concentration signal indicating values of the concentration of the component based on an output signal from a sensor that measures the concentration of the component;
a flatness calculator which calculates differences between the values of the concentration of the component indicated by the concentration signal over the plurality of time intervals of the expiratory waveform based on the concentration signal, and which calculates a flatness of the expiratory waveform based on the calculated differences;
a reliability calculator which calculates a reliability of the expiratory waveform based on the flatness and the values of the concentration of the component indicated by the concentration signal; and
a respiratory rate detecting portion which determines whether the expiratory waveform is reliable for inclusion in calculation of a respiratory rate of the subject based on the reliability of the expiratory waveform, and calculates the respiratory rate of the subject using the expiratory waveform in response to determining that the expiratory waveform is reliable and calculates the respiratory rate of the subject without inclusion of the expiratory waveform in response to determining that the expiratory waveform is not reliable.

2. The expiratory waveform analyzer according to claim 1 , wherein the flatness is a function of an accumulated value which is obtained by accumulating differences between the concentration of the component at time intervals during which the concentration of the component generating the expiratory waveform is measured by the sensor, based on the concentration signal.

3. The expiratory waveform analyzer according to claim 2 , wherein the flatness is a function of absolute values of the differences.

4. The expiratory waveform analyzer according to claim 2 , wherein the flatness is equal to:

1

{

Σ
⁡

(

D
⁢

⁢
Δ
⁢

⁢
t
⁢

⁢
CO
⁢

⁢
2

)

2

+
1

}

wherein DΔtCO2 is a difference between a current CO 2 concentration and a previous CO 2 concentration at time interval Δt.

5. The expiratory waveform analyzer according to claim 1 , wherein the reliability calculator calculates the reliability based on the flatness which is calculated at a timing by the flatness calculator, and the values of the concentration of the component indicated by the concentration signal at the timing.

6. The expiratory waveform analyzer according to claim 5 , further comprising:
an effective concentration detector which detects a value of the concentration signal at a timing when the reliability that is calculated in a predetermined concentration detecting time period is maximum, as an effective concentration of the component in the expiratory gas in the concentration detecting time period.

7. The expiratory waveform analyzer according to claim 6 , wherein the effective concentration detector accumulates the reliability in the concentration detecting time period to obtain an accumulated value in the concentration detecting time period, determines whether the expiratory waveform is reliable for inclusion in calculation of the effective concentration of the component in the expiratory gas of the subject based on whether the reliability in the concentration detecting time period exceeds a predetermined reliability, detects the effective concentration in the concentration detecting time period in response to determining that the expiratory waveform is reliable for inclusion in calculation of the effective concentration of the component in the expiratory gas of the subject and does not detect the effective concentration in the detecting time period in response to determining that the expiratory waveform is not reliable for inclusion in calculation of the effective concentration of the component in the expiratory gas of the subject, and calculates the effective concentration of the component in the expiratory gas of the subject, using the expiratory waveform if the expiratory waveform is reliable for inclusion in calculation of the effective concentration of the component in the expiratory gas of the subject and calculates the effective concentration of the component in the expiratory gas of the subject without inclusion of the expiratory waveform if the expiratory waveform is not reliable for inclusion in calculation of the effective concentration of the component in the expiratory gas of the subject.

8. The expiratory waveform analyzer according to claim 7 , wherein the concentration detecting time period is a time period corresponding to one cycle of the expiratory waveform.

9. The expiratory waveform analyzer according to claim 8 , further comprising:
a weighted average processor which, when a plurality of the effective concentrations are detected, weights each of the effective concentrations in accordance with degree of the accumulated value in the corresponding concentration detecting time period, and averages the weighted effective concentrations, to calculate a weighted average value.

10. The expiratory waveform analyzer according to claim 9 , further comprising:
a display that displays at least one of a number at which the effective concentration detector detects the effective concentration in a time period, and the weighted average value calculated by the weighted average processor.

11. The expiratory waveform analyzer according to claim 6 , wherein the expiratory gas concentration generator includes:
an expiratory gas concentration detector which converts an analog signal output from the sensor to a digital expiratory gas signal; and
an expiratory gas concentration calculator which generates the expiratory waveform signal based on the expiratory gas signal from the expiratory gas concentration detector,
the concentration signal is the expiratory waveform signal, and
when a value of the expiratory gas signal is a value or greater, which indicates that the concentration of the component is high, the effective concentration detector detects the effective concentration in the concentration detecting time period.

12. The expiratory waveform analyzer according to claim 11 , further comprising:
a concentration detecti

Assignees

• Aoki Toshiki
• Dainobu Hidetoshi
• Ukawa Teiji
• Echigo Masahiro
• Nihon Kohden Corp

Inventors

• Aoki Toshiki
• Dainobu Hidetoshi
• Ukawa Teiji
• Echigo Masahiro

Classifications

• G01N33/497

  of gaseous biological material, e.g. breath · CPC title

• A61B5/746

  Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms · CPC title

• G01N21/3504

  for analysing gases, e.g. multi-gas analysis · CPC title

• A61B5/7221

  Determining signal validity, reliability or quality (preventing, reducing or removing noise induced by motion artefacts A61B5/7207; noise originating from a therapeutic or surgical apparatus A61B5/7217) · CPC title

• A61B5/7203

  for noise prevention, reduction or removal · CPC title