Microchip solution sending system

Patent metadata

Field	Value
Publication number	US-9952210-B2
Application number	US-201214116219-A
Country	US
Kind code	B2
Filing date	May 8, 2012
Priority date	May 9, 2011
Publication date	Apr 24, 2018
Grant date	Apr 24, 2018

Abstract

A microchip solution sending system may include a flow passage assembly that is at least provided with a fine flow passage that is provided with a detection region including a formed reaction field to which an antibody that reacts with a specific antigen is fixed; and a micro pump that is connected to the flow passage assembly and that is configured to send a specimen material solution that includes the specific antigen in a reciprocating manner. The specimen material solution that has been sent may pass through the detection region in a repetitive manner in the case in which the micro pump sends the specimen material solution in a reciprocating manner.

First claim

The invention claimed is:

1. A microchip solution sending system for use with a specimen material solution, the system comprising:
a flow passage assembly comprising a fine flow passage comprising a detection region comprising a formed reaction field to which an antibody that reacts with a specific antigen is fixed; and
a micro pump that is connected to the flow passage assembly and that is structured to send the specimen material solution that includes the specific antigen in a reciprocating manner,
wherein the specimen material solution that has been sent passes through the detection region in a repetitive manner in the case in which the micro pump sends the specimen material solution in a reciprocating manner,
the microchip solution sending system comprises a controller structured to measure the amount of a solution that is sent from the micro pump, and reverse the solution sending direction of the micro pump,
the fine flow passage further comprises:
a first inflow outflow hole that is formed at the edge part of one side of the fine flow passage;
a second inflow outflow hole that is formed at the edge part of the other side of the fine flow passage;
a one side flow passage part where the reaction field is not formed, the one side flow passage part connecting the first inflow outflow hole and the detection region; and
an other side flow passage part where the reaction field is not formed, the other side flow passage part connecting the detection region and the second inflow outflow hole;
wherein the one side flow passage part, the detection region, and the other side flow passage part are coaxial; and
wherein a cross-sectional area of the fine flow passage is approximately equivalent along its length;

the flow passage assembly further comprises:
a one side flow passage that is connected to the fine flow passage via the first inflow outflow hole in such a manner that a solution can be passed through; and
an other side flow passage that is connected to the fine flow passage via the second inflow outflow hole in such a manner that a solution can be passed through, and
the micro pump is connected to the one side flow passage, and
the other side flow passage is a mixing part that is configured to store the specimen material solution that has passed through the detection region of the fine flow passage on a temporary basis and to stir the specimen material solution that has been stored, and

wherein the controller is structured to measure the amount of a solution that is sent from the micro pump, and control the micro pump to reverse the solution sending direction of the specimen material solution when the measured amount of the sent solution reaches a predetermined amount of the sent solution, such that the specimen material solution is reciprocated between the detection region and the mixing part;
wherein the controller is structured to control the micro pump such that approximately all of the specimen material solution passes the detection region before the solution sending direction is reversed; and
wherein at least one of the first inflow outflow hole and the second inflow outflow hole has a central axis nonparallel to a central axis of the fine flow passage.

2. The microchip solution sending system as defined in claim 1 , wherein the microchip solution sending system is used for a surface plasmon resonance apparatus (an SPR apparatus) or a surface plasmon-field enhanced fluorescence spectroscopic measurement apparatus (an SPFS apparatus).

Assignees

• Yamamoto Noriaki
• Aoki Youichi
• Konica Minolta Inc

Inventors

• Yamamoto Noriaki
• Aoki Youichi

Classifications

• G01N2035/106

  by sucking and blowing · CPC title

• B01L2300/0877

  Flow chambers · CPC title

• B01L2400/0487

  fluid pressure, pneumatics · CPC title

• B01L3/502715 Primary

  characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces · CPC title

• B01L2200/0605

  Metering of fluids · CPC title