Human IL-23 antigen binding proteins

Patent metadata

Field	Value
Publication number	US-9951129-B2
Application number	US-201615271315-A
Country	US
Kind code	B2
Filing date	Sep 21, 2016
Priority date	Oct 26, 2009
Publication date	Apr 24, 2018
Grant date	Apr 24, 2018

Abstract

Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.

First claim

What is claimed is:

1. An isolated nucleic acid molecule encoding one or both variable regions of an antigen binding protein that binds IL-23, wherein the antigen binding protein comprises at least one heavy chain variable region comprising: a CDRH1 of SEQ ID NO: 91, a CDRH2 of SEQ ID NO:92, and a CDRH3 of SEQ ID NO: 93; and at least one light chain variable region comprising: a CDRL1 of SEQ ID NO: 62, a CDRL2 of SEQ ID NO:63, and a CDRL3 of SEQ ID NO:64.

2. An isolated nucleic acid molecule encoding one or both variable regions of an isolated antigen binding protein that binds IL-23, wherein the antigen binding protein comprises a heavy chain variable region comprising amino acid residues 31-35, 50-65 and 99-113 of SEQ ID NO:31; and a light chain variable region comprising amino acid residues 23-36, 52-58 and 91-101 of SEQ ID NO:1.

3. An isolated nucleic acid molecule encoding one or both variable regions of an isolated antigen binding protein that binds IL-23, wherein the antigen binding protein comprises a heavy chain variable region of SEQ ID NO: 31 and a light chain variable region of SEQ ID NO: 1.

4. The isolated nucleic acid molecule of claim 3 , wherein the nucleic acid encoding the heavy chain variable region is SEQ ID NO:32.

5. The isolated nucleic acid molecule of claim 3 , wherein the nucleic acid encoding the light chain variable region is SEQ ID NO:2.

6. The isolated nucleic acid molecule of claim 3 , wherein the nucleic acid encoding the heavy chain variable region is SEQ ID NO:32 and the nucleic acid encoding the light chain variable region is SEQ ID NO:2.

7. A nucleic acid molecule according to claim 1 , 2 or 3 , wherein said nucleic acid molecule is operably linked to a control sequence.

8. A nucleic acid molecule according to claim 6 , wherein said nucleic acid molecule is operably linked to a control sequence.

9. An isolated vector comprising a nucleic acid molecule according to claim 1 , 2 or 3 .

10. An isolated vector comprising a nucleic acid molecule according to claim 6 .

11. An isolated host cell comprising the nucleic acid molecule according to claim 1 , 2 or 3 .

12. An isolated host cell comprising the nucleic acid molecule according to claim 6 .

13. An isolated host cell comprising the vector according to claim 9 .

14. An isolated host cell comprising the vector according to claim 10 .

15. A method of making an antigen binding protein that binds IL-23 comprising the step of collecting said antigen binding protein from a host cell of claim 11 , wherein the host cell comprises nucleic acid encoding both the heavy chain variable region and the light chain variable region of the antigen binding protein.

16. A method of making an antigen binding protein that binds IL-23 comprising the step of collecting said antigen binding protein from a host cell of claim 12 , wherein the host cell comprises nucleic acid encoding both the heavy chain variable region and the light chain variable region of the antigen binding protein.

17. A method of making an antigen binding protein that binds IL-23 comprising the step of collecting said antigen binding protein from a host cell of claim 13 , wherein the host cell comprises nucleic acid encoding both the heavy chain variable region and the light chain variable region of the antigen binding protein.

18. A method of making an antigen binding protein that binds IL-23 comprising the step of collecting said antigen binding protein from a host cell of claim 14 , wherein the host cell comprises nucleic acid encoding both the heavy chain variable region and the light chain variable region of the antigen binding protein.

Assignees

• Amgen Inc

Inventors

• Towne Jennifer E
• Cheng Janet D
• O'Neill Jason C
• Zhang Yu
• Sun Yu
• Cerne Heather
• Piper Derek E
• Ketchem Randal R

Classifications

• A61P37/00

  Drugs for immunological or allergic disorders · CPC title

• C07K2317/92

  Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value · CPC title

• C07K2317/55

  Fab or Fab' · CPC title

• C07K2317/24

  containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered · CPC title

• A61K47/6845

  the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon · CPC title