P2x3 and/or p2x2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof
US-2024400592-A1 · Dec 5, 2024 · US
US9951094B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9951094-B2 |
| Application number | US-201515112499-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 22, 2015 |
| Priority date | Jan 24, 2014 |
| Publication date | Apr 24, 2018 |
| Grant date | Apr 24, 2018 |
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The following formula is an example of a phosphole compound of the present invention. The phosphole compound of the present invention has the characteristic of maintaining a high fluorescence quantum yield in a wide range of solvents from low-polarity solvents to high-polarity solvents, as well as the characteristic in which the fluorescence wavelength shifts to the longer wavelength side as the polarity of the solvent increases. Because of these characteristics, the phosphole compound of the present invention is expected to be used, for example, for quantitatively determining the polarity in the environment therearound by using the absorption wavelength and fluorescence wavelength thereof, or used as a new fluorescent probe dye or a highly efficient luminescent material in organic electronic devices.
Opening claim text (preview).
The invention claimed is: 1. A phosphole compound represented by the following formula (2): wherein in formula (2), R 1 represents an aryl group or a substituted aryl group; R 3 and R 4 are the same and are each an alkyl group, a substituted alkyl group, an aryl group, or a substituted aryl group; R 5 and R 6 are the same and are each an alkyl group, a substituted alkyl group, an aryl group, or a substituted aryl group; Ar represents a hydrocarbon aromatic ring or a substituted hydrocarbon aromatic ring; n is 0; π 1 is a benzene ring; and —NR 3 R 4 is located at the 5- or the 6-position of the indene ring. 2. The phosphole compound according to claim 1 , wherein Ar is a benzene ring or a naphthalene ring. 3. The phosphole compound according to claim 2 , wherein R 3 and R 4 are each an alkyl group or a substituted alkyl group. 4. A fluorescent dye containing the phosphole compound according to claim 1 .
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