Selective inhibitor of angiotensin II

Patent metadata

Field	Value
Publication number	US-9944677-B2
Application number	US-201414776601-A
Country	US
Kind code	B2
Filing date	Mar 12, 2014
Priority date	Mar 15, 2013
Publication date	Apr 17, 2018
Grant date	Apr 17, 2018

Abstract

Peptides and peptide analogs that selectively inhibit angiotensin II are described. Additionally, a method for making and using the peptides and peptide analogs are also described.

First claim

What is claimed is:

1. A selective inhibitor of angiotensin II consisting essentially of amino acids having the sequence MAGFLSE (SEQ ID NO: 2).

2. The selective inhibitor of angiotensin II of claim 1 , wherein glycine is replaced with sarcosine.

3. A method of treating hypertension in a subject comprising administering a composition comprising the selective inhibitor of angiotensin II of claim 1 to the subject.

Assignees

• Univ Georgetown

Inventors

• Sandberg Kathryn
• Liu Jun
• Ji Hong

Classifications

• A61P9/12

  Antihypertensives · CPC title

• C07K14/72 Primary

  for hormones {(for neuromediators C07K14/70571)} · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• C07K7/06 Primary

  having 5 to 11 amino acids · CPC title