Eye mounted device for therapeutic agent release
US-12167978-B2 · Dec 17, 2024 · US
US9943688B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9943688-B2 |
| Application number | US-201113163506-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 17, 2011 |
| Priority date | Jun 18, 2010 |
| Publication date | Apr 17, 2018 |
| Grant date | Apr 17, 2018 |
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The present invention is wireless visual prosthesis with a remote driver for the external coils this, among other things, provides for a magnetic resonance image (MRI) safe visual prosthesis. fMRI is an effective tool for analyzing cortical responses to neural stimulation, such as from a visual prosthesis. However, the external electronics of a visual prosthesis cannot operate in a MRI field. The present invention provides a radio frequency shielded link between a video processing unit, driver circuitry and the coils used for communicating with the implantable portion of the visual prosthesis.
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What we claim is: 1. A visual prosthesis comprising: a video processing unit configured to provide stimulation signals; a driver circuit configured to receive signals from the video processing unit including a power amplifier; an external coil driven by the power amplifier and configured to transmit the stimulation signals; a bidirectional radio frequency shielded link configured to connect the driver circuit to the external coil, through a tuning circuit, the bidirectional radio frequency shielded link, tuning circuit, and external coil configured to operate within a controlled environment test system, the controlled environment test system selected from a group consisting of magnetic resonance imaging, positron emission tomography, magnetoencephalography and electroencephalography, the driver circuit not configured to operate within the controlled environment test system, and the bidirectional radio frequency shielded link being long enough to separate the video processing unit and driver circuit from the controlled environment test system; an implantable neural stimulator configured to operate within the controlled environment test system, the controlled environment test system suitable for testing cortical responses and providing measurements of cortical responses; and an implantable coil electrically connected to the implantable neural stimulator configured to receive stimulation signals from the external coil. 2. The visual prosthesis according to claim 1 , wherein the controlled environment is a magnetic resonance imaging field. 3. The visual prosthesis according to claim 1 , wherein the controlled environment is a positron emission tomography field. 4. The visual prosthesis according to claim 1 , wherein the controlled environment is a magnetoencephalography field. 5. The visual prosthesis according to claim 1 , wherein the bidirectional radio frequency shielded link includes a coaxial cable. 6. The visual prosthesis according to claim 5 , wherein the tuning circuit is between the coaxial cable and the external coil. 7. The visual prosthesis according to claim 6 , wherein the tuning circuit includes a non-ferrite core inductor. 8. The visual prosthesis according to claim 1 , further comprising a primary back telemetry coil electrically connected to the implantable neural stimulator and a secondary back telemetry coil electrically connected to the video processing unit through a second radio frequency shielded link. 9. The visual prosthesis according to claim 8 , further comprising a low noise amplifier between the second radio frequency shielded link and the video processing unit. 10. The visual prosthesis according to claim 8 , wherein the second radio frequency shielded link includes a coaxial cable. 11. A visual prosthesis comprising: a video processing unit configured to provide stimulation signals; a driver circuit configured to receive signals from the video processing unit including a power amplifier; an external coil driven by the power amplifier and configured to transmit the stimulation signals; a bidirectional radio frequency shielded link greater than one foot in length, the bidirectional radio frequency shielded link being long enough to connect the driver circuit to the external coil through a tuning circuit, the bidirectional radio frequency shielded link, tuning circuit, and external coil, configured to operate within a controlled environment test system, the controlled environment test system selected from a group consisting of magnetic resonance imaging, positron emission tomography, magnetoencephalography and electroencephalography, the driver circuit not configured to operate within the controlled environment test system; an implantable neural stimulator configured to operate within the controlled environment test system, the controlled environment test system suitable for testing cortical responses, and providing measurements of cortical responses; an implantable coil electrically connected to the implantable neural stimulator configured to receive stimulation signals from the external coil. 12. The visual prosthesis according to claim 11 , wherein the bidirectional radio frequency shielded link includes a coaxial cable. 13. The visual prosthesis according to claim 12 , wherein the tuning circuit is between the coaxial cable and the external coil. 14. The visual prosthesis according to claim 13 , wherein the tuning circuit includes a non-ferrite core inductor. 15. The visual prosthesis according to claim 11 , further comprising a primary back telemetry coil electrically connected to the implantable neural stimulator and a secondary back telemetry coil electrically connected to the video processing unit through a second radio frequency shielded link. 16. The visual prosthesis according to claim 15 , wherein the second radio frequency shielded link includes a coaxial cable. 17. The visual prosthesis according to claim 15 , wherein the second radio frequency shielded link includes a tuning circuit between the coaxial cable and the secondary back telemetry coil. 18. The visual prosthesis according to claim 15 , further comprising a low noise amplifier between the second radio frequency shielded link and the video processing unit. 19. The visual prosthesis according to claim 11 , wherein the bidirectional radio frequency shielded link is greater than five feet in length. 20. The visual prosthesis according to claim 11 , wherein the bidirectional radio frequency shielded link is greater than ten feet in length. 21. A method of fitting a visual prosthesis comprising providing a visual prosthesis according to claim 1 ; stimulating neural tissue; measuring cortical responses to the stimulation of neural tissue; adjusting the visual prosthesis according to the measurements of cortical responses. 22. The method according to claim 21 , wherein the step of measuring cortical responses is measuring cortical responses with magnetic resonance imaging. 23. The method according to claim 21 , wherein the step of measuring cortical responses is measuring cortical responses with positron emission tomography imaging. 24. The method according to claim 21 , wherein the step of measuring cortical responses is measuring cortical responses with magnetoencephalography. 25. The method according to claim 21 , wherein the step of measuring cortical responses is measuring cortical responses with electroencephalography.
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