Methods for treatment of cancer with an anti-tigit antagonist antibody
US-2024424092-A1 · Dec 26, 2024 · US
US9943605B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9943605-B2 |
| Application number | US-201113995301-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 23, 2011 |
| Priority date | Dec 23, 2010 |
| Publication date | Apr 17, 2018 |
| Grant date | Apr 17, 2018 |
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The invention relates to (among other things) polymer-semaxanib moiety conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over the semaxanib moiety in unconjugated form.
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What is claimed is: 1. A compound encompassed by the formula: and pharmaceutically acceptable salts thereof, wherein n is from 3 to 10. 2. A composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient. 3. A composition of matter comprising a compound of claim 1 , wherein the compound is present in a dosage form. 4. The compound of claim 1 , wherein n is from 3 to 9. 5. The compound of claim 1 , wherein n is 3. 6. The compound of claim 1 , wherein n is 4. 7. The compound of claim 1 , wherein n is 5. 8. The compound of claim 1 , wherein n is 6. 9. The compound of claim 1 , wherein n is 7. 10. The compound of claim 1 , wherein n is 8. 11. The compound of claim 1 , wherein n is 9.
Antineoplastic agents · CPC title
Indoles, e.g. pindolol · CPC title
the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol · CPC title
in position 2 · CPC title
Heterocyclic compounds (A61K47/558 takes precedence) · CPC title
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