Composition for the treatment of refractory painful intervertebral disc related disorders and method for delivery thereof to treat thereto
US-2024358660-A1 · Oct 31, 2024 · US
US9943541B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9943541-B2 |
| Application number | US-201615543123-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 12, 2016 |
| Priority date | Jan 13, 2015 |
| Publication date | Apr 17, 2018 |
| Grant date | Apr 17, 2018 |
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A method of treating water to reduce or prevent bacterial infection in an aquatic organism may include administering a particulate kaolin clay to the water in a dosage sufficient to reduce the presence of at least one undesirable bacterial species present in the water, wherein the particulate kaolin clay has at least one property selected from: (a) a BET surface area of at least about 25 m 2 /g; (b) a particle size distribution such that at least about 80% by weight of the particles of kaolin clay have an equivalent spherical diameter of less than 2 microns as measured by Sedigraph; and (c) a particle size distribution such that at least about 25% by weight of the particles of kaolin clay have an equivalent spherical diameter of less than 0.25 microns as measured by Sedigraph. The method may further include contacting an aquatic organism with the treated water.
Opening claim text (preview).
What is claimed is: 1. A method of treating water to reduce or prevent bacterial infection in a fish, the method comprising: administering a particulate kaolin clay to the water in a dosage sufficient to reduce the presence of at least one undesirable bacterial species present in the water; wherein the particulate kaolin clay comprises: (a) a BET surface area ranging from about 25 m 2 /g to about 40 m 2 /g; (b) a particle size distribution such that at least about 80% by weight of the particles of kaolin clay have an equivalent spherical diameter of less than 2 microns as measured by Sedigraph; and (c) a particle size distribution such that at least about 50% by weight of the particles of kaolin clay have an equivalent spherical diameter of less than 0.25 microns as measured by Sedigraph; and contacting a fish with the water, wherein the particulate kaolin clay is administered to the water at a dosage ranging from about 0.01 g/L to about 3 g/L, wherein the shape factor of the kaolin clay multiplied by the percentage by weight of the particles of kaolin clay having an equivalent spherical diameter of less than 0.25 microns as measured by Sedigraph has a valve of at least about 1000, and wherein the specific surface area of the kaolin clay multiplied by the percentage by weight of the particles of kaolin clay having an equivalent spherical diameter of less than 0.25 microns as measured by Sedigraph has a value of at least about 600. 2. The method of claim 1 , wherein the particulate kaolin clay has a particle size distribution such that at least about 85% by weight of the particles of kaolin clay have an equivalent spherical diameter of less than 2 microns as measured by Sedigraph. 3. The method of claim 1 , wherein the particulate kaolin clay has a particle size distribution such that at least about 90% by weight of the particles of kaolin clay have an equivalent spherical diameter of less than 2 microns as measured by Sedigraph. 4. The method of claim 1 , wherein specific surface area of the kaolin clay multiplied by the percentage by weight of the particles of kaolin day having an equivalent spherical diameter of less than 0.25 microns as measured by Sedigraph has a value of at least about 1000. 5. The method of claim 1 , wherein the particulate kaolin clay is administered to the water at a dosage ranging from about 0.1 g/L to about 0.8 g/L. 6. The method of claim 1 , wherein the particulate kaolin clay includes not more than 0.1% by weight dispersant. 7. The method of claim 1 , wherein the at least one undesirable bacterial species includes Flavobacterium columnare. 8. The method of claim 1 , wherein the fish is selected from catfish, tilapia, carp, salmon, sea bass, eels, mullet, bream, amberjack, grouper, perch, trout, sturgeon, or turbot. 9. The method of claim 1 , wherein the kaolin is a sedimentary kaolin.
Sorbent size or size distribution, e.g. particle size · CPC title
Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006) · CPC title
being less than 100 m2/g · CPC title
using inorganic sorbents · CPC title
Naturally occurring clays or bleaching earth · CPC title
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