Diagnostic and therapeutic methods and products related to anxiety disorders

Patent metadata

Field	Value
Publication number	US-9939449-B2
Application number	US-201213983114-A
Country	US
Kind code	B2
Filing date	Feb 1, 2012
Priority date	Feb 1, 2011
Publication date	Apr 10, 2018
Grant date	Apr 10, 2018

Abstract

The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.

First claim

We claim:

1. A method for diagnosing and treating post traumatic stress disorder (PTSD) in a female human, comprising:
a) analyzing pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in a tissue sample collected from a female human;
b) diagnosing PTSD in the female human having elevated tissue PACAP expression levels as compared to a control tissue sample obtained from a subject who does not have PTSD; and
c) administering to the female human diagnosed in (b) a therapeutically effective amount of an antibody that binds specifically to an epitope at the carboxy-terminal end of PACAP.

2. The method of claim 1 , wherein the female human exhibits at least one endophenotype of PTSD.

3. The method of claim 2 , wherein the at least one PTSD endophenotype is selected from the group consisting of: intrusive re-experiencing, avoidance, hyperarousal, and fear discrimination.

4. The method of claim 1 , wherein the PACAP expression levels comprise PACAP-38 and PACAP-27 expression levels.

5. The method of claim 1 , wherein the PACAP expression levels comprise PACAP-38 expression levels.

6. The method of claim 1 , wherein the analyzing of PACAP expression levels in the tissue sample is by radioimmunoassay.

7. The method of claim 1 , wherein the tissue sample is selected from the group consisting of blood, serum, plasma, and cerebrospinal fluid (CSF).

8. The method of claim 7 , wherein the tissue sample is blood.

Assignees

• May Victor
• Ressler Kerry J
• Hammack Sayamwong E
• Toufexis Donna
• Braas Karen M
• The Univ Of Vermont And State Agricultural College

Inventors

• May Victor
• Ressler Kerry J
• Hammack Sayamwong E
• Toufexis Donna
• Braas Karen M

Classifications

• C12Q2600/112

  Disease subtyping, staging or classification · CPC title

• C12Q2600/156

  Polymorphic or mutational markers · CPC title

• G01N2800/301

  Anxiety or phobic disorders · CPC title

• G01N2333/5757

  Vasoactive intestinal peptide [VIP] or related peptides · CPC title

• C12Q2600/154

  Methylation markers · CPC title