Indole compounds for use in treating inflammation and cancer
US-9597316-B2 · Mar 21, 2017 · US
Disubstituted triazole analogs
US9938246B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9938246-B2 |
| Application number | US-201615282312-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 30, 2016 |
| Priority date | Mar 31, 2014 |
| Publication date | Apr 10, 2018 |
| Grant date | Apr 10, 2018 |
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- Title
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- Abstract
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Abstract
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The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound, the compound of Formula (I): wherein: R 1 , R 5 and R 6 are hydrogen and R 2 , R 3 , and R 4 are independently chosen from hydrogen, methoxy, and hydroxyl, with the proviso that at least two of R 2 , R 3 , and R 4 are methoxy; and Ar is an aryl or substituted aryl group. 2. The compound of claim 1 , wherein Ar is chosen from phenyl, benzyl, substituted benzyl, benzoyl, substituted benzoyl, naphthyl, substituted naphthyl, naphthoyl, substituted naphthoyl, benzenesulphonyl, substituted benzenesulphonyl, heteroaryl; substituted heteroaryl, aroyl, heteroaroyl. 3. The compound of claim 1 , wherein the compound is Formula (I)(a): 4. The compound of claim 1 , wherein the compound is Formula (I)(b): 5. The compound of claim 1 , wherein the compound is Formula (I)(c): 6. The compound of claim 1 , wherein the compound is Formula (I)(d): 7. The compound of claim 1 , wherein the compound is Formula (I)(e): 8. The compound of claim 1 , wherein the compound is Formula (I)(f): 9. A pharmaceutical composition comprising a compound of Formula (I): wherein: R 1 , R 5 , and R 6 are hydrogen and R 2 , R 3 , and R 4 are independently chosen from hydrogen, methoxy, and hydroxyl, with the proviso that at least two of R 2 , R 3 , and R 4 are methoxy; and Ar is an aryl or substituted aryl group. 10. The pharmaceutical composition of claim 9 , wherein the compound of Formula (I) is selected from the group comprising Formula (I)(a), (I)(b), (I)(c), (I)(d), (I)(e), and (I)(f). 11. A compound, the compound selected from the group consisting of:
Assignees
Inventors
Classifications
Antineoplastic agents · CPC title
- C07D249/06Primary
with aryl radicals directly attached to ring atoms · CPC title
directly linked by a ring-member-to-ring-member bond · CPC title
directly linked by a ring-member-to-ring-member bond · CPC title
directly linked by a ring-member-to-ring-member bond · CPC title
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Frequently asked questions
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- What does patent US9938246B2 cover?
- The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided.
- Who is the assignee on this patent?
- Madadi Nikhil Reddy, Penthala Narsimha Reddy, Crooks Peter, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07D249/06. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).