Adsorption carrier-packed column

Patent metadata

Field	Value
Publication number	US-9937440-B2
Application number	US-201414889904-A
Country	US
Kind code	B2
Filing date	May 30, 2014
Priority date	May 31, 2013
Publication date	Apr 10, 2018
Grant date	Apr 10, 2018

Abstract

An adsorption carrier-packed column includes a central pipe, adsorption carrier, plate A, and plate B, wherein an insertion material C is inserted between the adsorption carrier and the plate A; an insertion material D is inserted between the adsorption carrier and the plate B; the ratio of the deformation rate of the insertion material C (C 1 ) to the deformation rate of the adsorption carrier (E 0 ) is 1<C 1 /E 0 <10, and the ratio of the deformation rate of the insertion material D (D 1 ) to the deformation rate of the adsorption carrier (E 0 ) is 1<D 1 /E 0 <10; and the ratio of the thickness of the insertion material C (T C ) to the distance of a gap between the adsorption carrier and the plate A (L A ) is 1.1<T C /L A <4, and the ratio of the thickness of the insertion material D (T D ) to the distance of a gap between the adsorption carrier and the plate B (L B ) is 1.1<T D /L B <4.

First claim

The invention claimed is:

1. A radial flow adsorption carrier-packed column comprising:
a central pipe in which at least one pore is provided to allow outflow of a supplied liquid, wherein the at least one pore is formed on at least one longitudinal side surface of the central pipe;
an adsorption carrier packed on a circumference of said central pipe to allow adsorption of at least one target molecule or at least one target cell contained in said liquid;
a plate A communicating with an upstream end of said central pipe such that said inflowing liquid passes through said central pipe, said plate A being arranged such that contacting of said liquid with said adsorption carrier without passing through said central pipe is prevented; and
a plate B arranged such that a downstream end of said central pipe is sealed and said adsorption carrier is immobilized in a space in a circumference of said central pipe;

wherein
an insertion material C is inserted between said adsorption carrier and said plate A;
an insertion material D is inserted between said adsorption carrier and said plate B;
a ratio (C 1 /E 0 ) of a deformation rate C 1 of said insertion material C to a deformation rate E 0 of said adsorption carrier is 1≤C 1 /E 0 ≤10, and a ratio (D 1 /E 0 ) of a deformation rate D 1 of said insertion material D to a deformation rate E 0 of said adsorption carrier is 1≤D 1 /E 0 ≤10; and
a ratio (T C /L A ) of a thickness T C of said insertion material C to a distance L A of a gap between said adsorption carrier and said plate A is 1.1≤T C /L A ≤4, and a ratio (T D /L B ) of a thickness T D of said insertion material D to a distance L B of a gap between said adsorption carrier and said plate B is 1.1≤T D /L B ≤4.

2. The adsorption carrier-packed column according to claim 1 , wherein the ratio (T C /L A ) of the thickness T C of said insertion material C to the distance L A of the gap between said adsorption carrier and said plate A is 3≤T C /L A ≤4, and the ratio (T D /L B ) of the thickness T D of said insertion material D to the distance L B of the gap between said adsorption carrier and said plate B is 3≤T D /L B ≤4.

3. The adsorption carrier-packed column according to claim 2 , wherein said insertion materials C and D are independently selected from the group consisting of rubber, gel, sponge, non-woven fabric and combinations thereof.

4. The adsorption carrier-packed column according to claim 2 , wherein said adsorption carrier includes means for processing blood.

5. The adsorption carrier-packed column according to claim 2 , wherein said adsorption carrier includes means for removing IL-6 from said liquid.

6. The adsorption carrier-packed column according to claim 1 , wherein said insertion materials C and D are independently selected from the group consisting of rubber, gel, sponge, non-woven fabric and combinations thereof.

7. The adsorption carrier-packed column according to claim 6 , wherein said adsorption carrier includes means for processing blood.

8. The adsorption carrier-packed column according to claim 6 , wherein said adsorption carrier includes means for removing IL-6 from said liquid.

9. The adsorption carrier-packed column according to claim 1 , wherein said adsorption carrier includes means for processing blood.

10. The adsorption carrier-packed column according to claim 9 , wherein said adsorption carrier includes means for removing IL-6 from said liquid.

11. The adsorption carrier-packed column according to claim 1 , wherein said adsorption carrier includes means for removing IL-6 from said liquid.

Assignees

• Toray Industries

Inventors

• Tomita Naotoshi
• Shimada Kaoru
• Ueno Yoshiyuki

Classifications

• B01J20/3208

  Polymeric carriers, supports or substrates · CPC title

• A61M1/3679

  by absorption (A61M1/3675 takes precedence) · CPC title

• B01J2220/58

  Use in a single column · CPC title

• B01D15/22 Primary

  relating to the construction of the column · CPC title

• B01J20/28023

  Fibres or filaments (fibres or filaments in the form of membranes B01J20/28038; B01J20/28007 takes precedence) · CPC title