Curcumin conjugates for treating and preventing cancers

Patent metadata

Field	Value
Publication number	US-9937260-B2
Application number	US-201514977426-A
Country	US
Kind code	B2
Filing date	Dec 21, 2015
Priority date	Sep 19, 2008
Publication date	Apr 10, 2018
Grant date	Apr 10, 2018

Abstract

Conjugating LHRH to curcumin (LHRH- Curcumin ) substantially enhances the bioavailability of curcumin , targets it to cells expressing LHRH receptors, facilitates intravenous administration, and increases the anti-cancer efficacy of curcumin . The conjugate may be used against cancer cells that express the LHRH receptor: pancreas, prostate, breast, testicular, uterine, ovarian, melanoma. LH- Curcumin conjugates may be used against cancer cells that express the LH receptor: prostate, breast, ovary, testis, uterus, pancreas, and melanoma.

First claim

What is claimed:

1. A method for killing or inhibiting the growth of cells in a tumor in a mammal; wherein the tumor expresses a receptor for luteinizing hormone-releasing hormone or a receptor for luteinizing hormone; said method comprising administrating to the mammal an effective amount of a compound having the structure:

2. The method of claim 1 , wherein the tumor is cancerous.

3. The method of claim 2 , wherein the tumor is selected from the group consisting of melanoma and cancers of the pancreas, prostate, breast, ovary, testis, and uterus.

4. The method of claim 1 , wherein the tumor is non-cancerous.

5. The method of claim 2 , wherein the tumor is a uterine fibroid.

6. The method of claim 2 , wherein the tumors a pancreatic cancer.

7. The method of claim 2 , wherein the tumor is a prostate cancer.

8. The method of claim 2 , wherein the tumor is a breast cancer.

9. The method of claim 2 , wherein the tumor is an ovarian cancer.

10. The method of claim 2 , wherein the tumor is a testis cancer.

11. The method of claim 2 , wherein the tumor is a uterine cancer.

Assignees

• Univ Louisiana State
• Board Of Supervisors Of Louisiana State Univ
• Agricultural And Mech College

Inventors

• Hansel William
• Aggarwal Sita
• Hammer Robert P

Classifications

• A61P35/00

  Antineoplastic agents · CPC title

• C07K7/23

  Luteinising hormone-releasing hormone [LHRH]; Related peptides · CPC title

• A61K47/54

  the modifying agent being an organic compound · CPC title

• A61K38/24

  Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH] · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title