Tetrahydrocurcumin compositions, methods of making, and methods of using the same
US-12115138-B2 · Oct 15, 2024 · US
US9937133B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9937133-B2 |
| Application number | US-201515307155-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 1, 2015 |
| Priority date | May 2, 2014 |
| Publication date | Apr 10, 2018 |
| Grant date | Apr 10, 2018 |
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The present invention relates an aldehyde dehydrogenase inhibitor for use in the treatment or prevention of fibrosis.
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The invention claimed is: 1. A method for treating or preventing mucous membrane pemphigoid (MMP) in a patient in need thereof, the method comprising administering to said patient an aldehyde dehydrogenase inhibitor, wherein the aldehyde dehydrogenase inhibitor is tetraethylthioperoxydicarbonic diamide (disulfiram) or 4-(diethylamino)benzaldehyde (DEAB). 2. The method according to claim 1 , wherein the aldehyde dehydrogenase inhibitor is tetraethylthioperoxydicarbonic diamide (disulfiram). 3. The method according to claim 1 , wherein the aldehyde dehydrogenase inhibitor is 4-(diethylamino)benzaldehyde (DEAB). 4. The method according to claim 1 , wherein the fibrosis is ocular mucous membrane pemphigoid (OcMMP).
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having the amino group directly attached to the aromatic ring, e.g. benzeneamine · CPC title
having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2) (isothiourea A61K31/155) · CPC title
Aromatic amines, i.e. where the amino group is directly linked to the aromatic nucleus · CPC title
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