Materials and methods for delivering compositions to selected tissues

Patent metadata

Field	Value
Publication number	US-9937129-B2
Application number	US-201615004790-A
Country	US
Kind code	B2
Filing date	Jan 22, 2016
Priority date	Apr 16, 2007
Publication date	Apr 10, 2018
Grant date	Apr 10, 2018

Abstract

This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.

First claim

What is claimed is:

1. A method of preparing a composition for controlled drug delivery comprising:
providing a porous silicon film;
heating the porous silicon film in an oxidizing environment at a temperature above 600° C.,
preparing particles from the oxidized porous silicon film; and
treating the oxidized porous silicon particles with a drug or biologically active material.

2. The method of claim 1 , wherein the particles have a size of between about 0.1 μm and about 100 μm.

3. The method of claim 1 , wherein the porous silicon film comprises pores with a free volume of from 50% to 80%.

4. The method of claim 1 , wherein the drug or biologically active material is a protein.

5. The method of claim 4 , wherein the drug or biologically active material is bevacizumab, ranibizumab, or pegaptanib.

6. The method of claim 1 , wherein the drug of biologically active material is selected from the group consisting of angiostatic steroids, metalloproteinase inhibitors, VEGF binding drugs, PEDF, an 8-mer peptide fragment of urokinase (uPA), and dexamethasone.

7. The method of claim 1 , wherein the drug or biologically active material targets a disease or disorder of the eye.

8. The method of claim 7 , wherein the disease or disorder of the eye is selected from the group consisting of: age-related macular degeneration (AMD), choroidal neovascularization (CNV), uveitis, diabetic retinopathy, retinovasclar disease, retinal detachment (PVR), and glaucoma.

9. The method of claim 1 , wherein the porous silicon film comprises a layered nanostructure.

10. The method of claim 1 , comprising the step of heating the porous silicon film in an oxidizing environment at a temperature above 700° C.

11. The method of claim 1 , comprising the step of heating the porous silicon film in an oxidizing environment at a temperature above 800° C.

12. The method of claim 1 , wherein particles are prepared from the oxidized porous silicon film after the porous silicon film is heated in an oxidizing environment at a temperature above 600° C.

13. The method of claim 1 , wherein the porous silicon film comprises pores selectively dimensioned to obtain a desired reflective wavelength.

14. The method of claim 1 , further comprising the step of capping the porous silicon film with a polymeric material.

15. The method of claim 1 , wherein the porous silicon film comprises pores configured to enhance binding efficacy of the drug or biologically active material.

Assignees

• Univ California

Inventors

• Freeman William R
• Sailor Michael J
• Cheng Lingyun

Classifications

• A61P9/12

  Antihypertensives · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P7/10

  Antioedematous agents; Diuretics · CPC title

• A61P7/00

  Drugs for disorders of the blood or the extracellular fluid · CPC title

• A61P7/02

  Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title